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首页> 外文期刊>Comparative biochemistry and physiology, Part B. Biochemistry & molecular biology >Distribution of estrogen-related receptors (ERR), human ERRγ and Drosophila ERR, as bisphenol A receptors
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Distribution of estrogen-related receptors (ERR), human ERRγ and Drosophila ERR, as bisphenol A receptors

机译：雌激素相关受体（ERR），人ERRγ和果蝇ERR作为双酚A受体的分布

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摘要

Estrogen-related receptor gamma (ERRγ) is a member of 48 human nuclear receptors. ERRγ is in a fully activated state with no ligand. We have recently demonstrated that ERRγ binds strongly bisphenol A (BPA), an endocrine disruptor, retaining its high constitutive activity. It is necessary for evaluating BPA’s endocrine disruption effects to analyze the expression profile of ERRγ. Since ERRγ has eight different mRNA splicing variants, we quantified the total and individual amounts of mRNAs by using total RNA extracts from 29 human tissues and 17 brain regions. The samples were measured by means of the capillary real-time PCR. It was found that ERRγ is widely expressed in the human tissues, and the mRNA isoforms are distributed in a tissue-specific manner. In particular, the placenta emerged as a tissue that expresses extremely highERRγ. Placenta is one of themost important endocrine reproductive organs whose adverse effects through ERRγ are now highly doubtful. In contrast with the presence of five different ERRγ-related nuclear receptors in human, the fruit fly Drosophila melanogaster has only a single nuclear receptor denoted as dERR.We found that dERR’s distribution is fairly diverse and that dERR also binds BPA considerably strongly.
机译：雌激素相关受体γ（ERRγ）是48种人类核受体的成员。 ERRγ处于完全活化状态，没有配体。最近，我们证明了ERRγ与内分泌干扰物双酚A（BPA）牢固结合，保留了其高构成活性。为了评估BPA的内分泌干扰作用，必须分析ERRγ的表达谱。由于ERRγ具有八个不同的mRNA剪接变体，因此我们通过使用来自29个人体组织和17个大脑区域的总RNA提取物来量化mRNA的总量和单个量。通过毛细管实时PCR测量样品。发现ERRγ在人体组织中广泛表达，并且mRNA亚型以组织特异性方式分布。特别地，胎盘表现为表达极高的ERRγ的组织。胎盘是最重要的内分泌生殖器官之一，其通过ERRγ引起的不良影响现在值得怀疑。与人类中存在五种不同的ERRγ相关核受体相反，果蝇果蝇仅具有一个单一的核受体，称为dERR。我们发现dERR的分布相当多样，并且dERR也与BPA牢固结合。

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