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首页> 外文期刊>感染症学雑誌 >Pathogenesis of beta-lactam-resistant Haemophilus influenzae isolated from sputum
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Pathogenesis of beta-lactam-resistant Haemophilus influenzae isolated from sputum

机译：痰中β-内酰胺耐药流感嗜血杆菌的发病机理

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摘要

Haemophlus influenzae persists in the respiratory tract and sometimes causes respiratory tract infections. To evaluate the pathogenesis of beta-lactam-resistant Haemophilus influenzae, we classified 193 Haemophilus influenzae strains isolated from sputum of patients with respiratory tract disease in 24 beta-lactamase positive (BLP) strains, 65 beta-lactamase negative ampicillin resistant (BLNAR) strains and 104 beta-lactamase negative ampicillin sensitive (BLNAS) strains and reviewed the pathogenesis of the strains. The pathogenesis of the strains was evaluated as definite pathogen, presumptive pathogen, colonization and contamination. It was judged to be the definite pathogen that many bacteria isolated from high quality sputum of the patients with respiratory tract infections. Presumptive pathogen was considered to be the bacteria provided from the patient with respiratory infections when the quality of the sputum or quantity of bacteria did not satisfy superscription basis. We considered the bacteria to be colonization or contamination isolated from patients without infections. The breakdown of definite pathogen/presumptive pathogen/colonization/contamination in each by groups was BLP (8/4/8/4), BLNAR (26/14/15/10), BLNAS (36/20/31/17). The ratio of definite or presumptive pathogen was 50% in BLP, 62% in BLNAR and 54% in BLNAS and the significant difference was not recognized in these. Pathogenesis of beta-lactam-resistant Haemophilus influenzae is estimated to be equal with beta-lactam-sensitive Haemophilus influenzae.
机译：流感嗜血杆菌在呼吸道中持续存在，有时会引起呼吸道感染。为了评估β-内酰胺耐药的流感嗜血杆菌的发病机理，我们将呼吸道疾病患者痰中分离出的193株流感嗜血杆菌分为24个β-内酰胺酶阳性（BLP）菌株，65个β-内酰胺酶阴性氨苄青霉素耐药（BLNAR）菌株和104个β-内酰胺酶阴性的氨苄青霉素敏感（BLNAS）菌株，并回顾了该菌株的发病机理。菌株的发病机理被评估为确定病原体，推定病原体，定植和污染。从呼吸道感染患者的高质量痰液中分离出许多细菌被认为是确定的病原体。当痰的质量或细菌数量不满足叠加标准时，推定病原体被认为是由呼吸道感染患者提供的细菌。我们认为细菌是从没有感染的患者中分离出来的定殖或污染。每个组的确定病原体/推定病原体/定殖/污染的分类为BLP（8/4/8/4），BLNAR（26/14/15/10），BLNAS（36/20/31/17）。明确或推测的病原体的比例在BLP中为50％，在BLNAR中为62％，在BLNAS中为54％，在这些中没有发现显着差异。估计β-内酰胺耐药的流感嗜血杆菌的发病机理与β-内酰胺敏感的流感嗜血杆菌相同。

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