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首页> 外文期刊>感染症学雑誌 >Usefulness of parenteral colistin in treating of lower respiratory infection due to multidrug-resistant Pseudomonas aeruginosa
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Usefulness of parenteral colistin in treating of lower respiratory infection due to multidrug-resistant Pseudomonas aeruginosa

机译：肠外大肠菌素在治疗多药耐药性铜绿假单胞菌引起的下呼吸道感染中的用途

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摘要

We report a case of cystic fibrosis in a 19-year-old woman who suffered from frequent exacerbations of lower respiratory infection due to multidrug-resistant Pseudomonas aeruginosa and who was successfully treated with parenteral colistin. Multidrug-resistant Pseudomonas aeruginosa isolated from sputum had become resistant to all parenteral antibiotics commercially available in Japan. She did not show clinical improvement despite treatment with several different combinations of available antibiotics. We therefore obtained parenteral colistin from a pharmacy outside Japan. She responded well to parenteral colistin without apparent side effects such as serious nephrotoxicity or neurotoxicity. Colistin is therefore an important alternative antibiotic for treating multidrug-resistant Pseudomonas aeruginosa and its use should be considered in severe infection. We hope that parenteral colistin will become available in Japan in the near future.
机译：我们报道了一名19岁妇女的囊性纤维化病例，该妇女由于对铜绿假单胞菌的多药耐药性而频繁下呼吸道感染加重，并成功通过肠胃外大肠菌素治疗。从痰液中分离出的具有多重耐药性的铜绿假单胞菌已对日本市售的所有肠胃外抗生素产生耐药性。尽管使用几种不同的可用抗生素组合进行治疗，但她并未显示出临床改善。因此，我们从日本以外的药店获得了肠胃外粘菌素。她对胃肠外粘菌素反应良好，没有明显的副作用，例如严重的肾毒性或神经毒性。因此，共利斯汀是治疗铜绿假单胞菌的一种重要替代抗生素，在严重感染中应考虑使用它。我们希望胃肠粘液大肠菌素能在不久的将来在日本上市。

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