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首页> 外文期刊>感染症学雑誌 >肺Mycobacterium avium complex (MAC)症の3姉妹例
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肺Mycobacterium avium complex (MAC)症の3姉妹例

机译：三姐妹患有​​禽分枝杆菌复杂性（MAC）疾病

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We reported three sisters of pulmonary Mycobacterium avium complex (MAC) disease. The oldest sister was complaining of bloody sputum, and cultures were positive for M. avium. By monother-apy with clarithromycin, symptom and imaging findings had shown no progression for six years. The second sister was complaining of productive cough, and cultures were positive for M. intracellulare. Her symptom and imaging findings had shown no progression for seven years without any treatment. The third sister had rheumatoid arthritis and diabetes mellitus, and cultures were positive for M. intracellulare. Although she received chemotherapy with rifampicin, clarithromycin, ethambutol, and kanamycin, symptom and imaging findings had progressed gradually. She died of respiratory failure four years later. Autopsy findings revealed no disseminated MAC disease. The results which three cases showed different isolate patterns and clinical courses suggest the importance of underlying anti-mycobacterial immunological impairment and defects of local host defense rather than virulence of infected strains as the pathogenesis of pulmonary MAC disease.
机译：我们报告了三个姐妹的肺鸟分枝杆菌复合体（MAC）疾病。最年长的姐姐抱怨痰中带血，而且禽鸟支原体培养呈阳性。通过单药与克拉霉素的治疗，症状和影像学结果显示六年没有进展。第二个姐姐抱怨咳嗽多产，而胞内分枝杆菌的培养呈阳性。她的症状和影像学表现未经任何治疗已显示7年无进展。第三姐姐患有类风湿关节炎和糖尿病，并且培养物中的细胞内分枝杆菌呈阳性。尽管她接受了利福平，克拉霉素，乙胺丁醇和卡那霉素的化学疗法，但症状和影像学发现已逐渐发展。四年后，她死于呼吸衰竭。尸检结果未发现传播性MAC疾病。三例病例的结果显示出不同的分离模式和临床过程，这说明了潜在的抗分枝杆菌免疫学损伤和局部宿主防御缺陷的重要性，而不是被感染菌株的毒力是肺MAC疾病的发病机理。

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