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首页> 外文期刊>感染症学雑誌 >Increasing drug resistance in Vibrio cholerae O1 and non-O1 strains isolated from diarrheal cases in Japan
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Increasing drug resistance in Vibrio cholerae O1 and non-O1 strains isolated from diarrheal cases in Japan

机译：日本从腹泻病例中分离出的霍乱弧菌O1和非O1菌株的耐药性增加

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Drug resistance trends were investigated for 271 Vibrio cholerae O1 (V.c O1) and 401 V. cholerae non-O1 (V.c non-O1) strains isolated from mainly imported diarrheal cases during 1981-2001 in Japan. The results of drug resistance test using 8 drugs (CP, TC, SM, KM, ABPC, ST, NA, and NFLX) showed that 34.7% of the V. c O1 strains and 15.7% of V.c non-O1 strains were multi-drug or mono-drug resistant. The incidence of drug resistant strains has increased since 1991, and it has been remarkable in V.c O1 strains that increased from 1.2% in 1981-1985 to 70.8% in 1996-2001. The drug resistance patterns of the resistant strains classified into 6 types in V.c O1 and 21 types in V.c non-O1. The prevalent patterns recognized were SM (75.5%), CP.TC.SM.ST (10.6%) and CP.SM.ST (8.5%) in V.c O1, and SM (25.4%) and ABPC (25.4%) in V.c non-O1. Ten V.c O1 strains (3.7%) and 10 V.c non-O1 strains (2.5%) were multi-drug resistant including TC. Among those, 13 strains were isolated from travelers who returned to Japan fromThailand. One V.c O1 strain (0.4%) and 6 V.c non-O1 strains (1.5%) were NA high-resistant and fluoroquinolones low-sensitive. Among those, 4 strains were isolated from travelers who returned to Japan from India.
机译：在1981-2001年间，对从主要进口的腹泻病例中分离出的271株霍乱弧菌O1（V.c O1）和401霍乱弧菌非O1（V.c nonO1）菌株的耐药性进行了调查。使用8种药物（CP，TC，SM，KM，ABPC，ST，NA和NFLX）进行的耐药性测试结果显示，V。c O1菌株中有34.7％和Vc non-O1菌株中有15.7％耐药或单药耐药。自1991年以来，耐药菌株的发生率有所增加，在V.c O1菌株中也很显着，从1981-1985年的1.2％增加到1996-2001年的70.8％。抗性菌株的耐药模式在V.c O1中分为6种，在V.c non-O1中为21种。在Vc O1中识别的流行模式是SM（75.5％），CP.TC.SM.ST（10.6％）和CP.SM.ST（8.5％），以及Vc中的SM（25.4％）和ABPC（25.4％）非O1。十株V.c O1菌株（3.7％）和10株V.c非O1菌株（2.5％）具有多重耐药性，包括TC。其中，从从泰国返回日本的旅行者中分离出13株。 1株V.c O1菌株（0.4％）和6株V.c非O1菌株（1.5％）是NA高抗性和氟喹诺酮类低敏感性。其中，有4株是从印度返回日本的旅客中分离出来的。

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