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首页> 外文期刊>感染症学雑誌 >Cytotoxic effect and influence of povidone-iodine on wounds in guinea pig
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Cytotoxic effect and influence of povidone-iodine on wounds in guinea pig

机译：聚维酮碘对豚鼠伤口的细胞毒性作用及其影响

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Cytotoxicity and effect on guinea pig wounds were compared with three kinds of 10% povidone-iodine solution (isodine, neojodine, J-iodine) and povidone-iodine. It gave the following results: 1. In the Chang conjunctiva cell where remarkable toxicity was observed in the used cell line, the toxicity emphasized was 10 times using povidone-iodine < J-iodine < neojodine < isodine. In addition, a toxic difference was recognized between cells, in the order of Chang conjunctiva > SIRC > FRSK > human fibroblast for isodine and neojodine. 2. As for the influence on cells achromatized in sodium thiosulfate, alteration was not recognized in isodine, J-iodine using half-maximum cytotoxicity concentrations (CC50), and, in neojodine and povidone-iodine, elimination of drug toxicity was recognized in Chang conjunctiva/FRSK cells. 3. Strong toxicity was seen in isodine and neojodine in the toxicity test using colony formation method, however on washing with PBS (-), an easing of the toxicity effect could be seen to 0.01%. 4. Polyoxythylene nonylphenyl ether, NP-10 was the most toxic in the used surfactants in this study, and the toxicity by 100 times when compared with sodium polyoxyethylene lauryl ether sulfate, SBL-2N. Prominent sensitivity was observed in Chang conjunctiva cells with regard to the cell line and subsequently showed toxicity in order of SIRC > FRSK > human fibroblast. Remarkably, the difference between solutions of isodine and J-iodine was made more clear from the 5th culture. 5. In this study, significantly guinea pig wounds, povidone-iodine blocked all examples significantly recognized as dallying by distance between epidermal cells. In addition, isodine was meaningful area. Although their ware not offer the significant differences, the solutions obstructed the sliding of epidermal cells in comparison with povidone-iodine, and a delaying tendency of inflammation was also recognized. The toxic difference between povidone iodine solutions was regarded as the influence of surfactants added to the povidone-iodine. Based on this foundation study, more detailed clinical testing is necessary in determine where sterilization to wounds/mucosa/eyes with solutions containing additive is a suitable panpractice or not.
机译：用三种10％聚维酮碘溶液（异碘，新jodine，J-碘）和聚维酮碘比较细胞毒性和对豚鼠伤口的影响。得到以下结果：1.在所用细胞系中观察到明显的毒性结膜细胞中，使用聚维酮-碘 SIRC> FRSK>人成纤维细胞对异碘和新jodine的顺序。 2.至于对硫代硫酸钠脱色的细胞的影响，使用半最大细胞毒性浓度（CC50），在异碘，J-碘中未发现改变，而在新d啶和聚维酮-碘中，Chang认识到药物毒性的消除。结膜/ FRSK细胞。 3.在使用菌落形成法进行的毒性试验中，异碘和新约旦碱具有很强的毒性，但是用PBS（-）洗涤后，毒性效果可降低至0.01％。 4.在这项研究中，聚氧乙烯壬基苯基醚NP-10在使用的表面活性剂中毒性最高，与聚氧乙烯月桂基醚硫酸钠SBL-2N相比，毒性是其100倍。在Chang结膜细胞中观察到关于细胞系的显着敏感性，并且随后以SIRC> FRSK>人成纤维细胞的顺序显示毒性。值得注意的是，从第5种培养物中可以更清楚地看出异碘和J-碘溶液之间的差异。 5.在这项研究中，豚鼠明显受伤，聚维酮-碘阻断了所有被表皮细胞之间距离显着提高的实例。另外，碘是有意义的领域。尽管它们的商品没有提供显着差异，但是与聚维酮碘相比，该溶液阻碍了表皮细胞的滑动，并且还认识到炎症的延迟趋势。聚维酮碘溶液之间的毒性差异被视为表面活性剂添加到聚维酮碘中的影响。根据这项基础研究，需要进行更详细的临床测试，以确定使用含添加剂的溶液对伤口/粘膜/眼睛进行灭菌的最佳实践。

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