In vitro evaluation of newly synthesised [1,2,4]triazolo[1,5a]pyrimidine derivatives against Trypanosoma cruzi, Leishmania donovani and Phytomonas staheli

Luque F.; Entrala E.; Rosales MJ.; Navarro JA.; Romero MA.; Salas JM.; Sanchez-Moreno M.; Fernandez-Ramos C.

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In vitro evaluation of newly synthesised [1,2,4]triazolo[1,5a]pyrimidine derivatives against Trypanosoma cruzi, Leishmania donovani and Phytomonas staheli

机译：新合成的[1,2,4]三唑并[1,5a]嘧啶衍生物在体外对克鲁氏锥虫，多形性利什曼原虫和番茄疫霉的评价

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The antiprotozoal activity of newly synthesised compounds, all [1,2,4]triazolo [1,5a]pyrimidine derivatives, was tested against the protozoan parasites Trypanosonza cruzi, Leishmania donovani and Phytomonas staheli. Six of these compounds significantly inhibited in vitro cell growth of the epimastigote forms of T. cruzi, and the promastigote forms of L. donovani and P. staheli. Some of the compounds reached complete growth inhibition at 1 mu g/ml for 48 h of parasite/drug interaction. None of the compounds tested showed significant toxicity against cells of Aedes albopictus, mouse macrophages J-774A.1 and Lycopersicum esculentum at dosages five times greater than used against parasites. (C) 2000 Elsevier Science Inc. All rights reserved. [References: 16]

机译：测试了所有[1,2,4]三唑并[1,5a]嘧啶衍生物的新合成化合物对原生动物寄生虫Trypanosonza cruzi，Leishmania donovani和Phytomonas staheli的抗原生动物活性。这些化合物中的六种显着抑制克鲁维氏锥虫的副鞭毛形式以及多诺尼和斯塔氏杆菌的前鞭毛体形式的体外细胞生长。一些化合物在1μg / ml的寄生虫/药物相互作用下48小时达到了完全的生长抑制。所测试的化合物均未显示出对白纹伊蚊，小鼠巨噬细胞J-774A.1和番茄的细胞具有显着的毒性，其剂量比对寄生虫的剂量大五倍。（C）2000 Elsevier Science Inc.保留所有权利。 [参考：16]

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《Comparative biochemistry and physiology, Part C. Pharmacology, toxicology and endocrinology: An international journal》 |2000年第1期|共6页
作者
Luque F.; Entrala E.; Rosales MJ.; Navarro JA.; Romero MA.; Salas JM.; Sanchez-Moreno M.; Fernandez-Ramos C.;
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正文语种 eng
中图分类内分泌生理;
关键词
Chemotherapy; Cytotoxicity; In vitro culture; Leishmania; Phytomonas; Trypanosoma; Chemotherapeutic-agents;

机译：化学疗法;细胞毒性;体外培养;利什曼原虫;假单胞菌;锥虫;化学治疗剂;

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1. In vitro evaluation of newly synthesised [1,2,4]triazolo[1,5a]pyrimidine derivatives against Trypanosoma cruzi,Leishmania donovani and Phytomonas Staheli [J] . F.Luque, C.Fernandez-Ramos, E.Entrala, Comparative biochemistry and physiology. Toxicology & pharmacology: CBP . 2000,第1期

机译：新合成的[1,2,4]三唑并[1,5a]嘧啶衍生物对克鲁斯锥虫，多形性利什曼原虫和番茄疫霉的体外评价
2. In vitro evaluation of newly synthesised [1,2,4]triazolo[1,5a]pyrimidine derivatives against Trypanosoma cruzi, Leishmania donovani and Phytomonas staheli [J] . Luque F., Entrala E., Rosales MJ., Comparative biochemistry and physiology, Part C. Pharmacology, toxicology and endocrinology: An international journal . 2000,第1期

机译：新合成的[1,2,4]三唑并[1,5a]嘧啶衍生物在体外对克鲁氏锥虫，多形性利什曼原虫和番茄疫霉的评价
3. Biochemical and ultrastructural alterations caused by newly synthesized 1,2,4-triazole(1,5a)pyrimidine derivatives against Phytomonas staheli (Trypanosomatidae). [J] . Luque F, Fernandez-Ramos C, Entrala E, Toxicology in vitro: an international journal published in association with BIBRA . 2000,第6期

机译：由新合成的1,2,4-三唑（1,5a）嘧啶衍生物对拟南芥（Phytomonas staheli）（Trypanosomatidae）引起的生化和超微结构改变。
4. The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives [O] . Stephanie Federico, Sara Redenti, Mattia Sturlese, 2010

机译：1-（3-三氟甲基苄基）-1H-吡唑-4-基对吡唑并[4,3-e] [1,2,4]三唑[1,5-]的腺苷受体亲和力的影响c]嘧啶衍生物
5. Heteroaromatization with 4-Hydroxycoumarin Part II: Synthesis of Some New Pyrano[2,3-d]pyrimidines, [1,2,4]triazolo[1,5-c]pyrimidines and Pyrimido[1,6-b]-[1,2,4]triazine Derivatives [O] . A. H. Bedair, A. H. Fakery, N. A. El-Hady, 2001

机译：4-羟基香豆素的异芳构化第二部分：一些新的吡喃并[2,3-d]嘧啶，[1,2,4]三唑并[1,5-c]嘧啶和嘧啶并[1,6-b] - [1]的合成，2,4]三嗪衍生物

In vitro evaluation of newly synthesised [1,2,4]triazolo[1,5a]pyrimidine derivatives against Trypanosoma cruzi, Leishmania donovani and Phytomonas staheli

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