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首页> 外文期刊>Comparative biochemistry and physiology, Part C. Pharmacology, toxicology and endocrinology: An international journal >Effect of 2-amino-4-phosphonobutyrate on the OFF responses of frog retinal ganglion cells and local ERG after glycinergic blockade
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Effect of 2-amino-4-phosphonobutyrate on the OFF responses of frog retinal ganglion cells and local ERG after glycinergic blockade

机译：2-氨基-4-膦酸丁酸酯对甘氨酸能受体阻断后青蛙视网膜神经节细胞OFF响应和局部ERG的影响

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摘要

Perfusion with the ON channel blocker 2-amino-4-phosphonobutyrater (APB) of dark adapted frog eyecups not only abolished the ganglion cells' (GC) ON responses and the ERG b-wave, but markedly potentiated the OFF responses of ON-OFF and phasic OFF-GCs and the d-wave amplitude of simultaneously recorded local ERG. Glycinergic blockade by strychnine prevented this potentiating effect in 31 out of 69 GCs, but did not change it at all in the other cells. At the same time the d-wave potentiation was preserved during the glycinergic blockade in all eyecups. The results indicate that glycinergic transmission is involved in the inhibition exerted from ON upon OFF channel in some but not all frog retinal GCs. (C) 2000 Elsevier Science S.A. All rights reserved. [References: 51]
机译：黑暗适应性青蛙眼罩的ON通道阻断剂2-氨基-4-膦酰丁酸（APB）灌注不仅消除了神经节细胞（GC）的ON反应和ERG b波，而且显着增强了ON-OFF的OFF反应。相位OFF-GC和同时记录的本地ERG的d波振幅。士的宁对甘草酸的阻断能在69个GC中的31个中阻止这种增强作用，但在其他细胞中根本没有改变。同时，在所有眼罩的甘氨酸能阻断期间，d波增强作用得以保留。结果表明，在一些但不是全部的青蛙视网膜GC中，甘氨酸能传递参与了从ON到OFF通道的抑制作用。 （C）2000 Elsevier Science S.A.保留所有权利。 [参考：51]

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