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首页> 外文期刊>Comparative biochemistry and physiology, Part C. Pharmacology, toxicology and endocrinology: An international journal >Muscle and serum changes with salbutamol administration in aerobically exercised rats
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Muscle and serum changes with salbutamol administration in aerobically exercised rats

机译:沙丁胺醇对有氧运动大鼠肌肉和血清的影响

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Treatment of experimental animals subjected to 90 days physical training programme plus repeated doses of salbutamol, a beta-adrenergic agonist, administered under two different regimes: therapeutic (16 mu g/kg body weight, twice a day) and doping (3 mg/kg body weight, twice a day), caused a marked increase in size of skeletal (soleus, gastrocnemius and plantaris) leg muscles. Adrenergic involvement of salbutamol-linked hypertrophy was demonstrated by co-administration of the non-specific beta-adrenergic antagonist D,L-propranolol (10 mg/kg body weight twice a day). The salbutamol-induced muscle hypertrophy was associated with an early increase in creatine phosphokinase (CK) and its myocardial isozyme (CKmb), without significant changes in lactate dehydrogenase (LDH), alanine aminotransferase (AAT) and aspartate aminotransferase (DAT). The induction of muscle-injury biomarkers was completely abolished by co-administration of propranolol, thus suggesting the adrenergic involvement of these alterations. (C) 2000 Elsevier Science Inc. All rights reserved. [References: 36]
机译:接受90天体育锻炼计划的实验动物的治疗,以及重复剂量的沙丁胺醇(一种β-肾上腺素能激动剂),在两种不同的治疗方案下给药:治疗性(16μg / kg体重,每天两次)和兴奋剂(3 mg / kg每天两次),导致腿部肌肉(比目鱼,腓肠肌和足底)肌肉明显增大。沙丁胺醇相关的肥大的肾上腺皮质受累通过非特异性β-肾上腺素拮抗剂D,L-普萘洛尔(每天两次,每次10 mg / kg体重)共同给药得到证实。沙丁胺醇诱导的肌肉肥大与肌酸磷酸激酶(CK)及其心肌同工酶(CKmb)的早期增加有关,而乳酸脱氢酶(LDH),丙氨酸氨基转移酶(AAT)和天冬氨酸氨基转移酶(DAT)没有明显变化。普萘洛尔的共同给药完全消除了肌肉损伤生物标志物的诱导,因此表明这些改变的肾上腺素能参与。 (C)2000 Elsevier Science Inc.保留所有权利。 [参考:36]

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