• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>感染症学雑誌 >Antibiotic activity of P. aeruginosa against MRSA and Candida albicans
【24h】

Antibiotic activity of P. aeruginosa against MRSA and Candida albicans

机译：铜绿假单胞菌对MRSA和白色念珠菌的抗菌活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The antibiotic activity demonstrated by P. aeruginosa (Bacillus pyocyaneus) has been reported more than one hundred years ago by Emmerich et al (1899). Studies on such bacterial interference between P. aeruginosa and other pathogenic bacteria or fungi have not been extensively reported in recent years. In this paper, we report on the anti MRSA activity and anti Candida activity demonstrated by clinical isolates of P. aeruginosa (34 strains). The antibiotic activity was tested by reversed agar plate method, as previously reported, and the degree of the activity was expressed as the diameter of the zone of growth inhibition. The stability of both anti MRSA activity and anti Candida activity was evaluated at the time after 24 and 48-hr incubation. Also the effect of agar plate with or without 5% sheep blood on antibiotic activity was evaluated. Strong anti MRSA activity and anti Candida activity was shown at the time after 24-hr incubation. At the time after 48-hr incubation, anti MRSA activities were significantly suppressed but anti Candida activities were persisted. The inhibitory activity was correlated with dye production of P. aeruginosa. Some strains having non or weak dye production, showed the inhibitory activity by 48-hr incubation. Result from these strains without suppression of anti Candida activity by additional blood may suggest that the existence of a new factor produced by P. aeruginosa. Because of frequent isolation of MRSA or Candida from clinical materials, we must consider bacterial flora and bacterial interference against pathogenic bacteria at the time of the antibiotic choice for the patients infected or colonized with P. aeruginosa.
机译：一百年前，Emmerich等人（1899年）就报道了铜绿假单胞菌（Pyocyaneus杆菌）所表现出的抗生素活性。近年来，尚未对铜绿假单胞菌与其他病原细菌或真菌之间的这种细菌干扰进行研究。在本文中，我们报道了由铜绿假单胞菌（34株）的临床分离株证明的抗MRSA活性和抗念珠菌活性。如先前报道，通过反向琼脂平板法测试抗生素活性，并且活性程度表示为生长抑制区的直径。在孵育24和48小时后评估抗MRSA活性和抗念珠菌活性的稳定性。还评估了有或没有5％羊血的琼脂平板对抗生素活性的影响。孵育24小时后，显示出较强的抗MRSA活性和抗念珠菌活性。孵育48小时后，抗​​MRSA活性被显着抑制，但抗念珠菌活性仍然存在。抑制活性与铜绿假单胞菌的染料产生相关。一些不产生或产生弱染料的菌株通过48小时温育表现出抑制活性。这些菌株的结果未通过额外的血液抑制抗念珠菌的活性，可能表明存在由铜绿假单胞菌产生的新因子。由于经常从临床材料中分离出MRSA或念珠菌，因此对于感染或定植于铜绿假单胞菌的患者，在选择抗生素时必须考虑细菌菌群和细菌对病原菌的干扰。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号