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A Complex Intervention for Workflow Enhancement at the Swedish Cervical Cytology Biobank

机译：瑞典宫颈细胞学生物库对提高工作流程的复杂干预

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摘要

The primary responsibility of biobanks is to collect biospecimens that are true reflections of the local population, thereby promoting translational research that is applicable to the community. The Swedish Cervical Cytology Biobank (SCCB) was designed as a hospital-integrated biobank in 2011. The SCCB has now been implemented in 10 county councils scattered across the country. It is headquartered at Karolinska University Hospital in Stockholm. The SCCB now processes more than 60% of the liquid-based gynecological cell samples obtained throughout Sweden. To improve the productivity of health care and research that rely on SCCB samples, a high level validation of the biobank system according to the principles of Good Laboratory Practices (GLP) is required. The performance of an entire high-throughput system validated by measuring the cell yield proved unsatisfactory after 1 year of sample collection and aliquoting. However, the results led to a number of high quality technical interventions for workflow enhancement. Subsequently, the improved process was applied to the system and led to a significant increase in cell yield. After the integration of the improved high quality methodology into the SCCB, the biobank services progressed more rapidly to serve the needs of personalized medicine and clinical studies. This enhancement was mainly due to the increased ability of the biobank to provide samples to research groups without any risk of leaving insufficient sample volumes for the care of the donor.
机译：生物库的主要责任是收集真实反映当地居民的生物样本，从而促进适用于社区的转化研究。瑞典宫颈细胞生物学库（SCCB）于2011年设计为医院整合的生物库。该SCCB现在已在全国10个县议会中实施。它的总部位于斯德哥尔摩的卡罗林斯卡大学医院。现在，SCCB处理了整个瑞典获得的超过60％的液态妇科细胞样本。为了提高依赖SCCB样本的卫生保健和研究的生产率，需要根据良好实验室规范（GLP）原则对生物库系统进行高水平验证。经过一年的样品收集和分装后，通过测量细胞产量验证的整个高通量系统的性能无法令人满意。但是，结果导致了许多用于增强工作流程的高质量技术干预措施。随后，将改进的过程应用于系统，并导致细胞产量的显着提高。在将改进的高质量方法学整合到SCCB中之后，生物库服务发展得更快，可以满足个性化医学和临床研究的需求。这种增强主要是由于生物库向研究小组提供样品的能力增强了，而又没有将足够的样品量留给捐献者的任何风险。

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