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首页> 外文期刊>Comparative biochemistry and physiology. Toxicology & pharmacology: CBP >The effects of the lampricide 3-trifluoromethyl-4-nitrophenol (TFM) on fuel stores and ion balance in a non-target fish, the rainbow trout (Oncorhynchus mykiss)
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The effects of the lampricide 3-trifluoromethyl-4-nitrophenol (TFM) on fuel stores and ion balance in a non-target fish, the rainbow trout (Oncorhynchus mykiss)

机译：杀菌剂3-三氟甲基-4-硝基苯酚（TFM）对非目标鱼类虹鳟（Oncorhynchus mykiss）的燃料存储和离子平衡的影响

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The pesticide 3-trifluoromethyl-4-nitrophenol (TFM) is used to control sea lamprey (Petromyzon marinus) populations in the Great Lakes through its application to nursery streams containing larval sea lampreys. TFM uncouples oxidative phosphorylation, impairing mitochondrial ATP production in sea lampreys and rainbow trout (Oncorhynchus mykiss). However, little else is known about its sub-lethal effects on non-target aquatic species. The present study tested the hypotheses that TFMexposure in hard water leads to (i) marked depletion of energy stores in metabolically active tissues (brain, muscle, kidney, liver) and (ii) disruption of active ion transport across the gill, adversely affecting electrolyte homeostasis in trout. Exposure of trout to 11.0 mg l~(?1) TFM (12-h LC_(50)) led to increases in muscle TFM and TFM-glucuronide concentrations, peaking at 9 h and 12 h, respectively. Muscle and brain glycogen was reduced by 50%, while kidney and muscle lactate increased with TFM exposure. Kidney ATP and phosphocreatine decreased by 50% and 70%, respectively. TFM exposure caused no changes inwhole body ion (Na~+, Cl~?, Ca2~+, K~+) concentrations, gill Na~+/K~+ ATPase activity, or unidirectional Na~+ movements across the gills. We conclude that TFM causes a mismatch between ATP supply and demand in trout, leading to increased reliance on glycolysis, but it does not have physiologically relevant effects on ion balance in hard water.
机译：通过将农药3-三氟甲基-4-硝基苯酚（TFM）应用于大湖中含有幼虫海鳗的苗圃溪流，可控制大湖中的海鳗（Petromyzon marinus）种群。 TFM使氧化磷酸化解偶联，从而削弱了七lamp鱼和虹鳟鱼（Oncorhynchus mykiss）中线粒体ATP的产生。但是，关于其对非目标水生物种的亚致死作用知之甚少。本研究检验了以下假设：硬水中的TFMexposure导致（i）代谢活跃组织（大脑，肌肉，肾脏，肝脏）中能量存储的明显消耗，以及（ii）穿过the的活跃离子运输受到破坏，对电解质产生不利影响鳟鱼体内平衡。鳟鱼暴露于11.0 mg l〜（？1）TFM（12-h LC_（50））导致肌肉TFM和TFM-葡糖醛酸的浓度增加，分别在9 h和12 h达到峰值。肌肉和脑糖原减少了50％，而肾脏和肌肉乳酸随TFM暴露而增加。肾脏ATP和磷酸肌酸分别降低了50％和70％。 TFM暴露不会引起体内离子（Na〜+，Cl〜？，Ca2〜+，K〜+）浓度，g Na〜+ / K〜+ ATPase活性或跨across的单向Na〜+运动。我们得出的结论是，TFM导致鳟鱼的ATP供需不匹配，导致对糖酵解的依赖性增加，但对硬水中的离子平衡没有生理相关的影响。

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