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首页> 外文期刊>藥學雜誌 >Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals.
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Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals.

机译：Dicranopteris linearis叶氯仿提取物在实验动物中的抗伤害和抗炎活性。

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摘要

The present study was carried out to establish the antinociceptive and anti-inflammatory properties of Dicranopteris linearis leaves chloroform extract in experimental animals. The antinociceptive activity was measured using the abdominal constriction, formalin and hot plate tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by evaporation under vacuo (40 degrees C) to dryness, was dissolved in dimethyl sulfoxide to the doses of 20, 100 and 200 mg/kg and administered subcutaneously 30 min prior to subjection to the above mentioned assays. The extract, at all doses used, was found to exhibit significant (p<0.05) antinociceptive activity in a dose-dependent manner. However, the significant (p<0.05) anti-inflammatory activity observed occur in a dose-independent manner. As a conclusion, the chloroform extract of D. linearis possesses antinociceptive and anti-inflammatory activity and thus justify its traditional uses by the Malays to treat various ailments.
机译：进行本研究以建立实验动物中线虫Dicranopteris linearis叶氯仿提取物的​​镇痛和抗炎特性。使用腹部收缩，福尔马林和热板试验测量抗伤害感受活性，而使用角叉菜胶诱导的足爪浮肿测量抗炎活性。将风干的叶子浸泡在氯仿中72小时，然后在真空（40摄氏度）下蒸发至干后获得的提取物溶于二甲基亚砜中，剂量为20、100和200 mg / kg，并皮下给药30在进行上述测定之前的3分钟。发现在所有使用剂量下，提取物均以剂量依赖性方式表现出显着的（p <0.05）抗伤害感受活性。但是，观察到的显着（p <0.05）抗炎活性以剂量无关的方式发生。结论是，线虫的氯仿提取物具有抗伤害感受和消炎作用，因此证明了马来人传统用途是治疗各种疾病。

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