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首页> 外文期刊>藥學雜誌 >Analysis of the factors associated with drugs remaining in the Diskhaler following inhalation of fluticasone propionate
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Analysis of the factors associated with drugs remaining in the Diskhaler following inhalation of fluticasone propionate

机译：吸入丙酸氟替卡松后与Diskhaler中残留药物有关的因素分析

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摘要

Because it is well known that drug remains in the fluticasone propionate Diskhaler (FP-DH) following a single inhalation, the following patient information is recommended. "Please inhale more than once or twice if any drug remains in the device after inhalation". It is believed the inspiratory flow rate of the individual patient has an influence on the amount of drug that remains in the device. If the dosing performance of FP-DH is dependent on inspiratory effort, establishment of a method of inhalation that makes it independent of inspiratory flow rate is important in clinical practice. In the present study, we investigated the influence of various methods of inhalation of drug remaining in the FP-DH. No significant differences were observed regarding the drug remaining in the device among the inhalation times examined (range, 0.5-2.5 s) or the number of inhalations (range, 1-3 times). On the other hand, the amount of drug remaining in the device did decrease by tapping the device before the second inhalation. The results suggest that the amount of drug remaining in the device can be decreased by tapping the device after the first inhalation if the patient's inspiratory flow rate is low.
机译：由于众所周知，单次吸入后药物会残留在丙酸氟替卡松Diskhaler（FP-DH）中，因此建议以下患者信息。 “如果吸入后药物残留在装置中，请吸入一两次以上。”据信，各个患者的吸气流速对装置中残留的药物量有影响。如果FP-DH的给药性能取决于吸气量，则在临床实践中建立一种使其独立于吸气流速的吸入方法非常重要。在本研究中，我们调查了吸入FP-DH中残留药物的各种方法的影响。在检查的吸入时间（范围为0.5-2.5 s）或吸入次数（范围为1-3次）之间，没有观察到关于装置中残留药物的显着差异。另一方面，通过在第二次吸入之前拍打设备，设备中残留的药物量确实减少了。结果表明，如果患者的吸气流速低，则可以在第一次吸入后通过轻敲设备来减少设备中残留的药物量。

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