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首页> 外文期刊>藥學雜誌 >Analysis of the factors associated with drugs remaining in the Diskhaler following inhalation of fluticasone propionate
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Analysis of the factors associated with drugs remaining in the Diskhaler following inhalation of fluticasone propionate

机译：吸入氟酮丙酸盐后止血剂残留物中剩余的药物的因素分析

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摘要

Because it is well known that drug remains in the fluticasone propionate Diskhaler (FP-DH) following a single inhalation, the following patient information is recommended. "Please inhale more than once or twice if any drug remains in the device after inhalation". It is believed the inspiratory flow rate of the individual patient has an influence on the amount of drug that remains in the device. If the dosing performance of FP-DH is dependent on inspiratory effort, establishment of a method of inhalation that makes it independent of inspiratory flow rate is important in clinical practice. In the present study, we investigated the influence of various methods of inhalation of drug remaining in the FP-DH. No significant differences were observed regarding the drug remaining in the device among the inhalation times examined (range, 0.5-2.5 s) or the number of inhalations (range, 1-3 times). On the other hand, the amount of drug remaining in the device did decrease by tapping the device before the second inhalation. The results suggest that the amount of drug remaining in the device can be decreased by tapping the device after the first inhalation if the patient's inspiratory flow rate is low.
机译：因为众所周知，在单一吸入后，药物保留在氟碳松丙酸甲酸盐（FP-DH）中，建议使用以下患者信息。 “如果任何药物在吸入后，请吸气超过一次或两次，如果吸入后的设备仍然存在”。据信，个体患者的吸气流速对装置中保留的药物量有影响。如果FP-DH的给药性能取决于吸气努力，建立一种吸入方法，使其独立于吸气流速在临床实践中是重要的。在本研究中，我们调查了各种吸入FP-DH中药物吸入的影响。在检测到的吸入时间（范围为0.5-2.5秒）或吸入的数量（范围，1-3次）中，没有观察到该装置中残留的药物没有显着差异。另一方面，通过在第二吸入前挖掘装置，装置中残留的药物的量减少。结果表明，如果患者的吸气流速低，则通过在第一次吸入后挖掘装置可以减少装置中残留的药物量。

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