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首页> 外文期刊>藥學雜誌 >コレステロール負荷食ウサギの脂質異常に対するPravastatin先発医薬品と後発医薬品の効果
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コレステロール負荷食ウサギの脂質異常に対するPravastatin先発医薬品と後発医薬品の効果

机译：普伐他汀原药和非专利药对高胆固醇饮食兔血脂异常的影响

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摘要

A systematic analysis for 11 ingredients of oral hypoglycemic agent in health foods was established using three different analytical methods; i.e. thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC) and comparison of MS/MS spectra analyzed by liquid chromatography/tandem mass spectrometry (LC/MS/ MS). In Normal-phase and reversed-phase TLC, each condition to separate and detect 10 ingredients except nateglinide was developed. On the other hand, 11 ingredients were detected qualitatively and quantitatively by HPLC. The recovery rates were 92-101 % and each coefficient of variation was less than 5.4%. Then UV spectra were monitored using this HPLC method and furthermore MS/MS spectra of 11 ingredients were obtained by LC/MS/MS. Identification of each ingredient became precise and rapid by comparing UV and MS/MS spectra of standard solutions with that of extract solutions from health foods. Using this systematic analysis, glibenclamide was accurately determined and identified from health foods.
机译：使用三种不同的分析方法，对保健食品中口服降糖药的11种成分进行了系统分析。即薄层色谱（TLC），高效液相色谱（HPLC）和通过液相色谱/串联质谱（LC / MS / MS）分析的MS / MS光谱比较。在正相和反相薄层色谱中，开发了分离和检测除那格列奈以外的10种成分的每种条件。另一方面，通过HPLC定性和定量检测了11种成分。回收率为92-101％，每个变异系数均小于5.4％。然后使用该HPLC方法监测UV光谱，并通过LC / MS / MS获得11种成分的MS / MS光谱。通过比较标准溶液的UV和MS / MS光谱与保健食品的提取液的光谱，可以精确，快速地鉴定每种成分。使用该系统分析，从保健食品中准确测定和鉴定了格列本脲。

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