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首页> 外文期刊>藥學雜誌 >コレステロール負荷食ウサギの脂質異常に対するPravastatin先発医薬品と後発医薬品の効果
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コレステロール負荷食ウサギの脂質異常に対するPravastatin先発医薬品と後発医薬品の効果

机译：Pharvastatin-领先的药物和排放后药物对胆固醇蔬菜的脂质异常的影响

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摘要

A systematic analysis for 11 ingredients of oral hypoglycemic agent in health foods was established using three different analytical methods; i.e. thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC) and comparison of MS/MS spectra analyzed by liquid chromatography/tandem mass spectrometry (LC/MS/ MS). In Normal-phase and reversed-phase TLC, each condition to separate and detect 10 ingredients except nateglinide was developed. On the other hand, 11 ingredients were detected qualitatively and quantitatively by HPLC. The recovery rates were 92-101 % and each coefficient of variation was less than 5.4%. Then UV spectra were monitored using this HPLC method and furthermore MS/MS spectra of 11 ingredients were obtained by LC/MS/MS. Identification of each ingredient became precise and rapid by comparing UV and MS/MS spectra of standard solutions with that of extract solutions from health foods. Using this systematic analysis, glibenclamide was accurately determined and identified from health foods.
机译：利用三种不同的分析方法建立了健康食品中11种成分的系统分析;即薄层色谱（TLC），高性能液相色谱（HPLC）和通过液相色谱/串联质谱（LC / MS / MS）分析的MS / MS光谱的比较。在正常相和反相TLC中，开发出除基因因素以外的10种成分的每个条件。另一方面，通过HPLC定性和定量检测11种成分。回收率为92-101％，每个变异系数小于5.4％。然后使用该HPLC方法监测UV光谱，并且通过LC / MS / MS获得11个成分的MS / MS光谱。通过将标准溶液的UV和MS / MS / MS光谱与来自健康食品的提取溶液的UV和MS / MS光谱比较，每种成分的鉴定精确且快速。使用该系统分析，精确确定并鉴定了Glibenclamide从健康食品中鉴定。

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