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首页> 外文期刊>Comparative Medicine >Differences in Memory Development among C57BL/6NCr1, 12952/SvPasCrl, and FVB/NCrl Mice after Delay and Trace Fear Conditioning
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Differences in Memory Development among C57BL/6NCr1, 12952/SvPasCrl, and FVB/NCrl Mice after Delay and Trace Fear Conditioning

机译：C57BL / 6NCr1，12952 / SvPasCrl和FVB / NCrl小鼠在延迟和痕量恐惧条件调节后的记忆发育差异

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Fear-conditioning testing paradigms have been used to study differences in memory formation between inbred mouse strains, including numerous mouse models of human diseases. In this study, we characterized the conditioned fear memory of 3 inbred strains: C57BL/6NCr1, 129S2/SvPasCrl, and FVB/NCrl, obtained from Charles River Laboratories. We used 2 training paradigms: delay conditioning, in which an unconditional stimulus coterminates with the presentation of a conditional stimulus, and trace conditioning, in which the conditional and unconditional stimuli are separated by a trace interval. In each paradigm, we evaluated the recent (3 d) and remote (25 d) memory of the mice by using a longitudinal design. Our results showed that both C57BL/6NCrl and 129S2/SvPasCrl mice developed strong and long-lasting context and tone memories in both paradigms, but FVB/NCrl mice showed a weaker but nevertheless consistent tone memory after delay training. Tone memory in the FVB strain was stronger in male than female mice. The remote tone memory of 129S2/SvPasCrl mice diminished after delay training but was stable and stronger than that of C57BL/6NCrl mice after trace training. In conclusion, both C57BL/6NCrl and 129S2/SvPasCrl mice showed reliable and long-lasting fear memory after delay or trace training, with 129 mice showing particularly strong tone memory after trace conditioning. The FVB/NCrl strain, especially male mice, showed reliable tone fear memory after delay training. Our findings confirm that both C57BL/6NCr1 and 129S2/SvPasCrl mice develop strong context and tone memory in delay and trace fear-conditioning paradigms.
机译：恐惧条件测试范例已用于研究近交小鼠品系之间的记忆形成差异，包括许多人类疾病的小鼠模型。在这项研究中，我们表征了从Charles River Laboratories获得的3个近交菌株的条件恐惧记忆：C57BL / 6NCr1、129S2 / SvPasCrl和FVB / NCrl。我们使用了2种训练范例：延迟条件（其中无条件刺激与条件刺激的呈现共同终止）和跟踪条件（其中跟踪条件与无条件刺激之间的间隔由跟踪间隔分隔）。在每个范例中，我们通过使用纵向设计评估了小鼠的近期记忆（3 d）和远程记忆（25 d）。我们的结果表明，C57BL / 6NCrl和129S2 / SvPasCrl小鼠在两种范式中均形成了强而持久的情境和语气记忆，但FVB / NCrl小鼠在延迟训练后显示出较弱但始终如一的语气记忆。在FVB品系中，雄性小鼠的记忆力强于雌性小鼠。 129S2 / SvPasCrl小鼠的延迟音训练在延迟训练后减弱，但比痕量训练后的C57BL / 6NCrl小鼠稳定和增强。总之，C57BL / 6NCrl和129S2 / SvPasCrl小鼠在延迟或跟踪训练后均表现出可靠而持久的恐惧记忆，而129小鼠在跟踪条件下表现出特别强的记忆力。 FVB / NCrl株，尤其是雄性小鼠，经过延迟训练后显示出可靠的语气恐惧记忆。我们的发现证实，C57BL / 6NCr1和129S2 / SvPasCrl小鼠在延迟和痕迹恐惧调节范例中均具有强大的背景和语气记忆能力。

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