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首页> 外文期刊>Comparative Medicine >Papiine herpesvirus 2 as a Predictive Model for Drug Sensitivity of Macacine herpesvirus 1 (Monkey B Virus)
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Papiine herpesvirus 2 as a Predictive Model for Drug Sensitivity of Macacine herpesvirus 1 (Monkey B Virus)

机译：Papiine疱疹病毒2作为Macacine疱疹病毒1（猴B病毒）药物敏感性的预测模型

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Monkey B virus (Macacine herpesvirus 1; BV) is endemic in macaques. BV (a BSL4 agent) is the primary zoonotic concern for persons working with macaques in research, and human BV infections frequently are fatal. We assessed the use of a BSL2 baboon herpesvirus (Papiine herpesvirus 1; HVP2) for predicting the drug sensitivity of BV by comparing the sensitivity of the 2 viruses to 12 antiherpetic drugs. Plaque reduction assays showed that 4 drugs (HBPG, BVdU, PFA, and BrdU) were ineffective against both viruses. Of the 8 effective drugs, both viruses were most sensitive to TFT, whereas sensitivity to the remaining 7 drugs varied between BV and HVP2 as well as between strains of HVP2. In addition, the efficacy of 5 drugs (ACV, PCV, GCV, CDV, and EDU) was tested by using a murine model. ACV and EDU were completely ineffective against both HVP2 and BV, and high doses of PCV only delayed death by a few days. GCV and CDV both protected mice against death, and CDV also prevented the development of neurologic symptoms. When the initiation of drug therapy was delayed until after virus gained access to the CNS, both GCV and CDV were ineffective. The similarity of the drug sensitivities of HVP2 and BV in both models validates the use of HVP2 as a BSL2 level model that can be used to predict drug sensitivity of By. The greater efficacy of CDV relative to GCV suggests the potential for use of CDV in the treatment of zoonotic BV infections.
机译：猴B病毒（Macacine疱疹病毒1; BV）在猕猴中流行。 BV（一种BSL4药物）是猕猴研究中主要的人畜共患病问题，人类BV感染常常是致命的。我们通过比较2种病毒对12种抗疱疹药物的敏感性，评估了BSL2狒狒疱疹病毒（Papiine疱疹病毒1; HVP2）在预测BV药物敏感性方面的应用。噬菌斑减少试验表明，四种药物（HBPG，BVdU，PFA和BrdU）对两种病毒均无效。在这8种有效药物中，两种病毒对TFT的敏感性最高，而对其余7种药物的敏感性在BV和HVP2以及HVP2株之间有所不同。此外，使用鼠模型测试了5种药物（ACV，PCV，GCV，CDV和EDU）的功效。 ACV和EDU对HVP2和BV完全无效，高剂量的PCV仅将死亡推迟了几天。 GCV和CDV都可以保护小鼠免于死亡，并且CDV也可以防止神经系统症状的发展。当药物治疗的开始推迟到病毒进入中枢神经系统后，GCV和CDV均无效。两个模型中HVP2和BV的药物敏感性相似，验证了HVP2作为BSL2水平模型的使用，可用于预测By的药物敏感性。 CDV相对于GCV的疗效更高，表明CDV可以用于治疗人畜共患的BV感染。

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