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首页> 外文期刊>Comparative Medicine >Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: Implications for mouse modeling
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Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: Implications for mouse modeling

机译：FVB / NCr小鼠的自发性垂体异常和乳腺增生：对小鼠建模的影响

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摘要

The FVB/N mouse strain is widely used in the generation of transgenic mouse models. We have observed that mammary glands of wild-type virgin female FVB/NCr mice frequently have the morphologic and histologic appearance of a gland during pregnancy. By 13 months of age, the mammary glands of more than 40% of the mice examined had lobuloalveolar hyperplasia that was characterized by the presence of secretory alveoli and distended ducts apparently containing secretory material. The prevalence of this phenotype further increased with age. The mammary phenotype was highly correlated with the presence of proliferative, prolactin-secreting lesions in the pituitary gland. In mice aged 18 to 23 months, hyperplasia of the pars distalis was seen in 11 of 21 mice (52%), and a further 4 of 21 mice (19%) had pituitary adenomas. Pituitary hyperplasia was already evident in some mice as young as nine months. The pituitary phenotype was also associated with high prevalence (4/6 mice) of spontaneous mammary tumors in aged multiparous, but not virgin FVB/NCr mice. This high prevalence of pituitary abnormalities and their effects on the mammary gland have important consequences for the interpretation of new phenotypes generated in transgenic models using this mouse substrain.
机译：FVB / N小鼠品系广泛用于转基因小鼠模型的产生。我们已经观察到野生型原始雌性FVB / NCr小鼠的乳腺在怀孕期间经常具有腺体的形态学和组织学外观。到13个月大时，超过40％的受检小鼠的乳腺患有肺泡小叶增生，其特征是存在分泌性肺泡和明显含有分泌性物质的扩张管。随着年龄的增长，该表型的患病率进一步增加。乳腺表型与垂体分泌增生性泌乳素的病变高度相关。在18至23个月大的小鼠中，在21只小鼠中有11只（52％）可见远端骨增生，而21只小鼠中还有4只（19％）患有垂体腺瘤。垂体增生在一些仅9个月大的小鼠中就已经很明显。垂体表型还与年龄较大的多胎，但未出生的FVB / NCr小鼠的自发性乳腺肿瘤高发生率（4/6小鼠）有关。垂体异常的高患病率及其对乳腺的影响对使用该小鼠亚菌株的转基因模型中产生的新表型的解释具有重要意义。

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