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首页> 外文期刊>Comparative Medicine >MRI Features in a Canine Model of Ischemic Stroke: Correlation between Lesion Volume and Neurobehavioral Status during the Subacute Stage.
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MRI Features in a Canine Model of Ischemic Stroke: Correlation between Lesion Volume and Neurobehavioral Status during the Subacute Stage.

机译：犬缺血性卒中模型的MRI特征：亚急性阶段病变体积与神经行为状态之间的相关性。

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摘要

The purpose of this study was to evaluate the diagnostic value of magnetic resonance imaging (MRI) and assess the correlation between the volume of the ischemic lesion and neurobehavioral status during the subacute stage of ischemic stroke. Ischemic stroke was induced in 6 healthy laboratory beagles through permanent occlusion of the middle cerebral artery (MCAO). T2-weighted and fluid-attenuated inversion recovery (FLAIR) imaging, diffusion-weighted imaging (DWI), measurement of the apparent diffusion coefficient (ADC) ratio, and neurobehavioral evaluation were performed 3 times serially by using a 1.5-T MR system: before and 3 and 10 d after MCAO. Ischemic lesions demonstrated T2 hyperintensity, FLAIR hyperintensity, and DWI hyperintensity. The ADC ratio was decreased initially but then was increased at 10 d after MCAO. Ischemic lesion volumes on T2-weighted and FLAIR imaging were not significantly different from those on DWI. The lesion volume and neurobehavioral score showed strong correlation. Our results suggest that conventional MRI may be a reliable diagnostic tool during the subacute stage of canine ischemic stroke.
机译：这项研究的目的是评估磁共振成像（MRI）的诊断价值，并评估缺血性卒中亚急性期缺血性病变的体积与神经行为状态之间的相关性。通过永久性阻塞大脑中动脉（MCAO），在6只健康的实验室小猎犬中诱发了缺血性中风。使用1.5-T MR系统连续进行了3次T2加权和液体衰减倒置恢复（FLAIR）成像，弥散加权成像（DWI），表观弥散系数（ADC）比的测量以及神经行为评估： MCAO之前，3和10 d之后。缺血性病变表现为T2高信号，FLAIR高信号和DWI高信号。 ADC比率最初降低，但在MCAO之后的10 d时增加。 T2加权和FLAIR成像上的缺血性病变体积与DWI上的无明显差异。病变体积与神经行为评分呈强相关。我们的结果表明，常规MRI在犬缺血性中风亚急性期可能是可靠的诊断工具。

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