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首页> 外文期刊>Comparative Medicine >Prevalence of viremia and oral shedding of rhesus rhadinovirus and retroperitoneal fibromatosis herpesvirus in large age-structured breeding groups of rhesus macaques (Macaca mulatta)
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Prevalence of viremia and oral shedding of rhesus rhadinovirus and retroperitoneal fibromatosis herpesvirus in large age-structured breeding groups of rhesus macaques (Macaca mulatta)

机译：恒河猴（Macaca mulatta）年龄结构大的繁殖群中恒河猴鼠鼻病毒和腹膜后纤维瘤病疱疹病毒的病毒血症和口腔脱落的发生率

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摘要

We performed a cross-sectional study to estimate the prevalence of 2 gamma-2-herpesviruses, rhesus rhadinovirus (RRV) and retroperitoneal fibromatosis herpesvirus (RFHV), in breeding colonies of rhesus macaques. Of 90 animals selected for sampling, 73 (81%) were positive for RRV, which was detected only in blood in 22 (24%), only in saliva in 15 (16%), and in both blood and saliva in 36 (40%). Detection of RRV DNA in blood and saliva was significantly higher in animals younger than 2 y. In comparison, RFHV was detected in 40 (44%) of the 90 animals: only in blood in 5 (6%), only in saliva in 26 (29%), and in both blood and saliva in 9 (10%). Dual infection was detected in 38 (42%) animals; RFHV was only detected in coinfections. The mean RRV genome copy number in blood was significantly higher than that for RFHV. Age was a significant predictor of RRV copy number in blood and RFHV copy number in saliva. Of the 90 animals, 88 (98%) were positive for rhadinoviral antibodies on an immunofluorescent assay. Both RRV and RFHV are highly endemic in socially housed breeding colonies of rhesus macaques, and their patterns of infection are similar to that for the betaherpesvirus rhesus cytomegalovirus.
机译：我们进行了一项横断面研究，以估计在恒河猴猕猴的繁殖群体中2种伽马2疱疹病毒，恒河猴鼻病毒（RRV）和腹膜后纤维瘤病疱疹病毒（RFHV）的患病率。在选择进行采样的90只动物中，有73（81％）的RRV阳性，仅在血液中检出22（24％），仅在唾液中检出15（16％），在血液和唾液中检出36（40） ％）。在2岁以下的动物中，血液和唾液中RRV DNA的检出率明显更高。相比之下，在90只动物中有40只（44％）检测到RFHV：仅在血液中检测到5只（6％），仅在唾液中检测到26只（29％），在血液和唾液中均检测到9只（10％）。在38只（42％）动物中检测到双重感染;仅在合并感染中检测到RFHV。血液中的RRV基因组平均拷贝数显着高于RFHV。年龄是血液中RRV拷贝数和唾液中RFHV拷贝数的重要预测指标。在这90只动物中，有88只（98％）在免疫荧光检测中呈狂犬病病毒抗体阳性。 RRV和RFHV在恒河猴猕猴的社会饲养繁殖区中都是高度流行的，它们的感染方式与乙型疱疹病毒恒河猴巨细胞病毒相似。

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