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首页> 外文期刊>Comparative Medicine >Helicobacter infection decreases reproductive performance of IL10-deficient mice
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Helicobacter infection decreases reproductive performance of IL10-deficient mice

机译：幽门螺杆菌感染会降低IL10缺陷小鼠的生殖能力

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Infections with a variety of Helicobacter species have been documented in rodent research facilities, with variable effects on rodent health. Helicobacter typhlonius has been reported to cause enteric disease in immunodeficient and IL10(-/-) mice, whereas H. rodentium has only been reported to cause disease in immunodeficient mice coinfected with other Helicobacter species. The effect of Helicobacter infections on murine reproduction has not been well studied. The reproductive performance of C57BL/6 IL10(-/-) female mice intentionally infected with H. typhlonius, H. rodentium, or both was compared with that of age-matched uninfected controls or similarly infected mice that received antihelicobacter therapy. The presence of Helicobacter organisms in stool and relevant tissues was detected by PCR assays. Helicobacter infection of IL10(-/-) female mice markedly decreased pregnancy rates and pup survival. The number of pups surviving to weaning was greatest in noninfected mice and decreased for H. rodentium > H. typhlonius H. rodentium and H. typhlonius coinfected mice. Helicobacter organisms were detected by semiquantitative real-time PCR in the reproductive organs of a subset of infected mice. Treatment of infected mice with a 4-drug regimen consisting of amoxicillin, clarithromycin, metronidazole, and omeprazole increased pregnancy rates, and pup survival and dam fecundity improved. We conclude that infection with H. typhlonius, H. rodentium, or both decreased the reproductive performance of IL10(-/-) mice. In addition, antihelicobacter therapy improved fecundity and enhanced pup survival.
机译：在啮齿动物研究设施中已记录到各种幽门螺杆菌感染，对啮齿动物的健康有不同的影响。据报道，台风幽门螺杆菌在免疫缺陷和IL10（-/-）小鼠中引起肠道疾病，而啮齿类杆菌仅在与其他幽门螺杆菌共感染的免疫缺陷小鼠中引起疾病​​。尚未充分研究幽门螺杆菌感染对小鼠生殖的影响。将C57BL / 6 IL10（-/-）故意感染鼠伤寒杆菌，啮齿类动物或两者感染的雌性小鼠的生殖性能与年龄相匹配的未感染对照或接受抗幽门螺杆菌治疗的类似感染小鼠的生殖性能进行了比较。通过PCR测定法检测粪便和相关组织中幽门螺杆菌的存在。 IL10（-/-）雌性小鼠的幽门螺杆菌感染显着降低了妊娠率和幼仔存活率。存活至断奶的幼崽数量在未感染的小鼠中最大，而对于啮齿类杆菌>鼠伤寒>鼠伤寒和鼠伤寒合并感染的小鼠，幼仔数量减少。通过半定量实时PCR在部分感染小鼠的生殖器官中检测到了幽门螺杆菌。用由阿莫西林，克拉霉素，甲硝唑和奥美拉唑组成的4药物疗法治疗受感染的小鼠可提高妊娠率，并提高幼崽的存活率和母鼠的生殖能力。我们得出的结论是，感染鼠伤寒杆菌，啮齿类杆菌或两者都降低了IL10（-/-）小鼠的繁殖性能。此外，抗幽门螺杆菌疗法改善了繁殖力，并提高了幼崽的存活率。

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