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首页> 外文期刊>Comparative Medicine >Efficacy of oral fecal bacteriotherapy in rhesus macaques (Macaca mulatta) with chronic diarrhea.
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Efficacy of oral fecal bacteriotherapy in rhesus macaques (Macaca mulatta) with chronic diarrhea.

机译：恒河猴恒河猴口服粪便细菌疗法的功效。

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Chronic diarrhea remains the principal burden in providing health care for nonhuman primates in biomedical research facilities. Although the exact etiology continues to puzzle nonhuman primate clinicians, recent research in humans has shown that restoring the indigenous microbial diversity may be successful in resolving cases of chronic diarrhea when other treatment modalities have failed. The process of restoring this microbial balance, known as fecal bacteriotherapy, uses the complete flora from a normal donor as a therapeutic probiotic mixture. In the current study, Indian-origin rhesus macaques were randomized into treatment (n=7) and control (n=6) groups to determine whether orally administered fecal bacteriotherapy would reduce the overall incidence of chronic diarrhea during a 60-d follow-up period in the treatment group compared with control macaques, which received a placebo. Although the treatment effect, determined by comparing the baseline fecal scores of the treatment and control groups, did not reach statistical significance, preprocedure and postprocedure fecal scores in the treatment group differed significantly. These findings are encouraging, and we hope that our study will motivate larger studies evaluating the use of fecal bacteriotherapy in nonhuman primates.
机译：慢性腹泻仍然是生物医学研究机构为非人类灵长类提供医疗保健的主要负担。尽管确切的病因继续困扰着非人类的灵长类动物临床医生，但人类的最新研究表明，当其他治疗方法均失败时，恢复本地微生物多样性可能会成功解决慢性腹泻。恢复这种微生物平衡的过程称为粪便细菌疗法，它使用来自正常供体的完整菌群作为治疗性益生菌混合物。在当前的研究中，印度源恒河猴被随机分为治疗组（n = 7）和对照组（n = 6），以确定口服粪便细菌疗法是否会降低60天随访期间慢性腹泻的总体发生率与接受安慰剂的对照组猕猴相比，治疗组的这一时期。尽管通过比较治疗组和对照组的基本粪便得分确定的治疗效果未达到统计学显着性，但治疗组的术前和术后粪便得分明显不同。这些发现令人鼓舞，并且我们希望我们的研究将激发更大的研究，以评估在非人类灵长类动物中使用粪便细菌疗法。

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