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首页> 外文期刊>Comparative Medicine >Using Hematology Data from Malaria Vaccine Research Trials in Humans and Rhesus Macaques (Macaca mulatta) To Guide Volume Limits for Blood Withdrawal
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Using Hematology Data from Malaria Vaccine Research Trials in Humans and Rhesus Macaques (Macaca mulatta) To Guide Volume Limits for Blood Withdrawal

机译：使用来自人类和恒河猴（Macaca mulatta）的疟疾疫苗研究试验的血液学数据来指导采血量限制

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Guidelines on safe volume limits for blood collection from research participants in both humans and laboratory animals vary widely between institutions. The main adverse event that may be encountered in large blood volume withdrawal is iron-deficiency anemia. Monitoring various parameters in a standard blood panel may help to prevent this outcome. To this end, we analyzed the Hgb and MCV values from 43 humans and 46 macaques in malaria vaccine research trials. Although the percentage of blood volume removed was greater for macaques than humans, macaques demonstrated an overall increase of MCV over time, indicating the ability to respond appropriately to frequent volume withdrawals. In contrast, humans showed a consistent declining trend in MCV. These declines in human MCV and Hgb were significant from the beginning to end of the study despite withdrawals that were smaller than recommended volume limits. Limiting the volume withdrawn to no more than 12.5% seemed to be sufficient for macaques, and at 14% or more individual animals tended to fail to respond appropriately to large-volume blood loss, as demonstrated by a decrease in MCV. The overall positive erythropoietic response seen in macaques was likely due to the controlled, iron-fortified diet they received. The lack of erythropoietic response in the human subjects may warrant iron supplementation or reconsideration of current blood volume withdrawal guidelines.
机译：在机构之间，关于从人类和实验动物的研究参与者采集血液的安全量限制的准则存在很大差异。大量抽血可能遇到的主要不良事件是缺铁性贫血。监视标准血液面板中的各种参数可能有助于防止这种结果。为此，我们在疟疾疫苗研究试验中分析了43名人类和46只猕猴的Hgb和MCV值。尽管猕猴的血液去除量百分比比人类大，但猕猴显示MCV随着时间的推移整体增加，表明有能力对频繁抽血做出适当的反应。相反，人类的MCV呈持续下降趋势。尽管撤回量小于建议的容量限制，但从研究开始到结束，人类MCV和Hgb的下降幅度仍然很大。对于猕猴来说，将抽水量限制在不超过12.5％似乎就足够了，并且在14％或更多的情况下，个别动物往往无法对大量失血做出适当的反应，如MCV下降所证明。在猕猴中看到的总体阳性的促红细胞生成反应很可能是由于他们接受受控的铁强化饮食所致。人类受试者缺乏促红细胞生成反应，可能需要补充铁或重新考虑当前的血容量戒断指南。

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