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首页> 外文期刊>Comparative Medicine >Ectoparasite Burden, Clinical Disease, and Immune Responses throughout Fur Mite (Myocoptes musculinus) Infestation in C57BL/6 and Rag1(-/-) Mice
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Ectoparasite Burden, Clinical Disease, and Immune Responses throughout Fur Mite (Myocoptes musculinus) Infestation in C57BL/6 and Rag1(-/-) Mice

机译：在C57BL / 6和Rag1（-/-）小鼠的整个螨螨（Myocoptes musculinus）感染中，寄生虫的负担，临床疾病和免疫反应

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Immunocompetent weanling mice infested with Myocoptes musculinus harbor high mite loads, yet burdens decrease with age. The development of immunity to the parasite may explain this observation. In this study, we followed M. musculinus burdens in Rag1(-/-) mice and immunocompetent C57BL/6 controls from 4 to 36 wk of age and compared the clinical signs and body weights of noninfested and infested mice of both strains over time. In addition, histopathology of skin lesions and expression of cytokines and transcription factors associated with Th1- and Th2-type immune responses were assessed. Myocoptes burdens decreased and remained low in B6 mice over time, whereas Rag1(-/-) mice showed an initial decrease in burdens after 4 wk of age followed by an increase from 24 to 36 wk. In addition, Rag1(-/-) mice had higher burdens than B6 mice over time. Both strains of infested mice exhibited clinical signs of fur mite infestation including alopecia, poor weight gain, mite-associated debris, and pruritus and clinical signs positively correlated with the severity of the Myocoptes burden. Histopathology of skin from both strains of infested mice showed decreased lesion severity with age, likely a result of declining mite populations. Finally, compared with noninfested controls, infested B6 mice had increased expression of markers associated with the Th2-type immune response, which increased in magnitude with increasing age and duration of infestation. These results suggest that development of adaptive immunity plays a role in control of fur mite populations and that heavier infestations may result in more severe clinical signs and skin lesions.
机译：感染了Myocoptes musculinus的免疫能力强的断奶小鼠螨虫含量高，但负担却随着年龄的增长而降低。对寄生虫免疫力的发展可能解释了这一发现。在这项研究中，我们追踪了从4周到36周龄的Rag1（-/-）小鼠和具有免疫能力的C57BL / 6对照中的小肠支原体负担，并比较了这两种菌株的未感染和感染小鼠的临床体征和体重随时间的变化。此外，评估了皮肤病变的组织病理学以及与Th1和Th2型免疫反应相关的细胞因子和转录因子的表达。随着时间的推移，B6小鼠的Myocoptes负担减少并保持较低水平，而Rag1（-/-）小鼠在4周龄后显示出最初的负担减轻，随后从24周增加至36周。另外，随着时间的推移，Rag1（-/-）小鼠的负担比B6小鼠更高。两种受感染小鼠的品系均表现出螨虫感染的临床体征，包括脱发，体重增加较差，与螨虫有关的碎片以及瘙痒，并且临床症状与Myocoptes负担的严重程度呈正相关。两种受感染小鼠的皮肤组织病理学研究均显示，随着年龄的增长，病变的严重程度降低，这可能是螨虫数量下降的结果。最后，与未感染的对照组相比，被感染的B6小鼠的Th2型免疫反应相关标志物的表达增加，其随年龄和感染持续时间的增加而增加。这些结果表明，适应性免疫的发展在控制螨虫种群中发挥了作用，而更严重的侵扰可能导致更严重的临床体征和皮肤病变。

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