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首页> 外文期刊>Comparative Medicine >Rhesus monkeys with late-onset hydrocephalus differ from non-impaired animals during neonatal neurobehavioral assessments: six-year retrospective analysis
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Rhesus monkeys with late-onset hydrocephalus differ from non-impaired animals during neonatal neurobehavioral assessments: six-year retrospective analysis

机译：新生神经行为评估中迟发性脑积水的恒河猴与非受损动物不同：六年回顾性分析

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Background and Purpose: A recent case study indicated that a hydrocephalic rhesus monkey had abnormal response patterns in a standardized neonatal primate assessment. We conducted a retrospective study to determine whether this assessment could alsodifferentiate neonatal rhesus monkeys that appeared normal but developed signs of hydrocephalus later in life from neonates with normal development and no evidence of hydrocephalus. Methods: One-hundred eighty-two rhesus monkeys were assessed on postnatal days 7, 14, 21, and 30. As neonates, clinical signs of hydrocephalus or other illnesses were not evident in any animal. Six monkeys developed signs of hydrocephalus between 5 months and 5 years of age, and each received confirmed diagnoses of hydrocephalus at necropsy. Results: Compared with colony norms, the monkeys that developed hydrocephalus had diminished orientation abilities, more muscle tension, less behavioral evidence of distress, and more pronounced responses to some reflexevoking stimuli, and difficulty in self-righting (day 7 only). Discriminant function analysis comparing the hydrocephalic animals with a matched control group provided a high probability of correct group assignment at days 7, 14, and 21. Conclusions: Some as yet undetermined factor may predispose some monkeys to develop hydrocephalus, which may also be reflected in different scores on neurodevelopmental test items during early infancy.
机译：背景与目的：最近的一项案例研究表明，在标准化的新生儿灵长类动物评估中，脑积水性猕猴的反应方式异常。我们进行了一项回顾性研究，以确定该评估是否也可以区分看起来正常但在生命后期出现脑积水迹象的新生恒河猴与发育正常且没有脑积水证据的新生儿。方法：在出生后的第7、14、21和30天评估了82只恒河猴。作为新生儿，在任何动物中都没有明显的脑积水或其他疾病的临床体征。 6只猴子在5个月至5岁之间出现了脑积水的迹象，每只在尸检时都得到了确诊为脑积水的诊断。结果：与殖民地规范相比，发展为脑积水的猴子的定向能力下降，肌肉紧张程度增加，遇难的行为证据更少，对某些反射性诱发刺激的反应更加明显，并且难以自我纠正（仅第7天）。判别功能分析将脑积水动物与匹配的对照组进行比较，在第7、14和21天时有较高的正确分组可能性。结论：一些尚未确定的因素可能使某些猴子易患脑积水，这也可能反映在婴儿早期在神经发育测试项目上的得分不同。

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