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首页> 外文期刊>Comparative Medicine >Gender differences in deep venous thrombosis in a rat model: a preliminary study
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Gender differences in deep venous thrombosis in a rat model: a preliminary study

机译：大鼠模型中深静脉血栓形成的性别差异：初步研究

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The purpose of this study was to determine whether gender differences have an effect on inflammation and thrombosis in a rat model of venous thrombosis. A thrombus was created in mature female (n = 12) and male (n = 12) Sprague Dawley rats (Rattus norvegicus) by ligating the inferior vena cava (IVC). The IVC containing the thrombus was harvested at 1 and 3 days postligation, weighed, measured, and submitted for immunohistochemical analysis. In addition, hematology was performed at selected time points. There were no statistically significant differences in thrombus mass (mean +/- 1 standard deviation) between female and male rats at 1 (683 +/- 47.7 x 10(-4) versus 660 +/- 112.0 x 10(-4) g/cm) or 3 (683 +/- 83.3 x 10(-4) versus 580 +/- 86.0 x 10(-4) g/cm) days post-ligation. Females had significantly more platelets than did males on day 1 (741 +/- 37.2 versus 523 +/- 55.1 K/microL, P < 0.01). Day 3 males showed significant increases in vein wall neutrophils (18.0 +/- 2.30 versus 11.2 +/- 1.38, P < 0.05), ED-1-positive monocytes (54.4 +/- 16.0 versus 18.7 +/- 5.63, P < 0.05), and circulating white blood cells (15.4 +/- 0.947 x 10(3) versus 10.9 +/- 0.714 x 10(3)/microL, P < 0.01) at post-thrombosis when compared with females. We conclude that although female rats had greater thrombus mass, the male rats demonstrated more inflammatory cells in circulation and in their vein walls. This finding suggests that inflammation plays a role in thrombus resolution.
机译：这项研究的目的是确定性别差异是否对大鼠静脉血栓形成模型的炎症和血栓形成有影响。通过结扎下腔静脉（IVC），在成年雌性（n = 12）和雄性（n = 12）Sprague Dawley大鼠（Rattus norvegicus）中产生血栓。结扎后第1天和第3天收集含有血栓的IVC，称重，测量并进行免疫组织化学分析。另外，在选定的时间点进行血液学检查。雌性和雄性大鼠在1（683 +/- 47.7 x 10（-4）g与660 +/- 112.0 x 10（-4）g时之间的血栓质量（均值+/- 1标准偏差）没有统计学上的显着差异/ cm）或3（683 +/- 83.3 x 10（-4）对580 +/- 86.0 x 10（-4）g / cm）天。在第1天，女性的血小板明显多于男性（741 +/- 37.2与523 +/- 55.1 K / microL，P <0.01）。第3天男性显示静脉壁中性粒细胞显着增加（18.0 +/- 2.30对11.2 +/- 1.38，P <0.05），ED-1阳性单核细胞（54.4 +/- 16.0对18.7 +/- 5.63，P <0.05 ）和血栓形成后与女性相比，循环白细胞（15.4 +/- 0.947 x 10（3）对10.9 +/- 0.714 x 10（3）/ microL，P <0.01）。我们得出的结论是，尽管雌性大鼠的血栓量更大，但雄性大鼠在循环中和静脉壁中显示出更多的炎性细胞。这一发现表明炎症在血栓形成中起作用。

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