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The effect of fostering on the genetic expression of locomotor sensitivity to alcohol

机译：培育对运动性酒精敏感性基因表达的影响

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Steps were taken to eradicate endemic mouse coronavirus from a colony that was part of a behavioral project characterizing the genetics of alcohol sensitivity. This behavioral study was conducted to determine whether changing the uterine or rearing environment (as is integral to common rederivation methods) would have a significant effect on the expression of the behavioral traits in question. Selected breeding pairs of the affected lines were divided into four treatment groups: 1) transfer of embryos to pseudopregnant B6D2F1 female mice, 2) fostering offspring to B6D2F1 dams, 3) fostering offspring to a different dam of the same line, and 4) offspring raised by the birth dam. Embryo transfers were successful only in one affected line. At approximately 50 days of age, the offspring were tested for locomotor behavior after intraperitoneal administration of ethanol or normal saline. There were no statistically significant effects of embryo transfer on the ethanol phenotype (ethanol-induced locomotor depression). Fostering significantly reduced the stimulant response to ethanol of only one mouse line selectively bred for high sensitivity to ethanol-induced stimulation, although the stimulant response of the fostered groups was still quite robust. Overall, the results of this study showed that eradication efforts involving fostering of offspring have a modest impact on the stimulant response to ethanol, but there were insufficient data to draw conclusions regarding the use of embryo transfer.
机译：已采取措施从一个殖民地根除地方性小鼠冠状病毒，这是表征酒精敏感性遗传学行为计划的一部分。进行了这项行为研究，以确定改变子宫或饲养环境（对于常见的重新分配方法是必不可少的）是否会对所讨论的行为特征的表达产生重大影响。将受影响的系的选定繁殖对分为四个处理组：1）将胚胎转移到假孕的B6D2F1雌性小鼠中; 2）将后代培育成B6D2F1母体; 3）将后代培育成同一系中的不同母体;以及4）后代由出生水坝抚养长大。胚胎移植仅在一个受影响的系中成功。在大约50天时，对腹腔内注射乙醇或生理盐水的孩子进行运动行为测试。胚胎移植对乙醇表型（乙醇诱导的运动抑制）没有统计学上的显着影响。寄养显着降低了仅一只小鼠品系对乙醇的刺激性反应，该小鼠品系对乙醇诱导的刺激高度敏感，因此被选择性饲养，尽管受养组的刺激性反应仍然十分强劲。总体而言，这项研究的结果表明，涉及培育后代的根除努力对乙醇的兴奋性反应影响不大，但没有足够的数据得出有关使用胚胎移植的结论。

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