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Refinement of Vascular Access Port Placement in Nonhuman Primates: Complication Rates and Outcomes

机译：在非人类灵长类动物中完善血管通路的位置：并发症发生率和结果。

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Chronic vascular access is often needed in experimental animal studies, and vascular access ports (VAP) have been proposed as an alternative to conventional venipuncture We previously reported on VAP implantation by using femoral venous cutdown (FVC) and tunneling In an attempt to decrease the moderate complications associated with the FVC method, we developed the single-incision, peripheral-insertion (SIP!) method In a retrospective evaluation, 92 FVC procedures were compared with 113 SIPI procedures in cynomolgus and rhesus macaques and baboons with as much as 2 5 y of follow-up The rate of complications was significantly lower for the SIPI method than for the FVC method (19 4% versus 33 7%), particularly in regard to infectious complications (8 0% versus 27 3%, respectively) In addition, VAP patency for blood sampling and fluid infusion was significantly better for the SIPI method than for the FVC method, with 1-y patency rate of 83% and 46%, respectively, and 2-y patency rate of 74% and 36%, respectively Additional advantages of the SIPI method include the simplified implantation of the VAP and access in the homecage without any sedation or restraint after appropriate training of animals to cooperate We conclude that the SIPI method presents an opportunity for refinement and is superior to the FVC method for chronic vascular access
机译：在动物实验研究中经常需要使用慢性血管通路，并且已经提出了将血管通路（VAP）替代常规静脉穿刺的方法。我们先前曾报道过通过股骨静脉切开术（FVC）和隧穿术来进行VAP植入，以试图降低中度与FVC方法相关的并发症，我们开发了单切口，外周插入（SIP！）方法。在回顾性评估中，比较了92例FVC程序与113例SIPI程序在食蟹，猕猴和狒狒中的发生率高达2 5年。随访：SIPI方法的并发症发生率显着低于FVC方法（19 4％对33 7％），特别是在感染性并发症方面（分别为8 0％对27 3％）。 SIPI方法的血液采样和输液的VAP通畅性明显优于FVC方法，其1年通畅率分别为83％和46％，2年通畅率为74 SIPI方法的其他优点分别包括：VAP的简化植入以及在适当的动物合作训练后没有任何镇静或约束的情况下在笼中的通入我们得出结论，SIPI方法提供了改进的机会，并且优越FVC方法用于慢性血管通路

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