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首页> 外文期刊>Comparative Medicine >Antigen recognition by serum antibodies in non-human primates experimentally infected with Mycobacterium tuberculosis
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Antigen recognition by serum antibodies in non-human primates experimentally infected with Mycobacterium tuberculosis

机译：实验性感染结核分枝杆菌的非人灵长类动物中血清抗体的抗原识别

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摘要

Tuberculosis is a significant threat to non-human primates and their caretakers. The diagnosis of tuberculosis in living non-human primates is currently based on the tuberculin skin test, which is cumbersome and sometimes inaccurate. Development of an accurate serodiagnostic test requires identification of the key antigens of Mycobacterium tuberculosis involved in antibody production. When sequential serum samples obtained from 17 cynomolgus, rhesus, and African green monkeys up to seven months since experimental infection with M. tuberculosis Erdman were screened for antibody against purified proteins of M. tuberculosis, three highly seroreactive antigens were identified. One protein, ESAT-6, reacted with sera from all infected animals. Two additional proteins, a-crystallin and MTSA-10, were recognized by sera from approximately 90% of infected animals. Time course analysis of antibody production indicated that the earliest response was usually to ESAT-6 alone or to ESAT-6 and other antigen(s). These results provide experimental evidence of the potential value of ESAT-6 as an antigen for use in serodiagnosis of tuberculosis in non-human primates.
机译：结核病是对非人类灵长类动物及其看护者的重大威胁。当前，非人类灵长类动物的结核病诊断基于结核菌素皮肤测试，该测试很麻烦，有时不准确。要开发准确的血清诊断测试，需要鉴定参与抗体生产的结核分枝杆菌的关键抗原。从结核分枝杆菌实验感染后长达七个月的17个食蟹猴，恒河猴和非洲绿猴获得的连续血清样品中，针对抗结核分枝杆菌纯化蛋白的抗体进行了筛选，从而鉴定出三种具有高度血清反应活性的抗原。一种蛋白质ESAT-6与所有感染动物的血清反应。血清中约有90％的感染动物识别出了另外两种蛋白质，α-晶状体蛋白和MTSA-10。抗体产生的时程分析表明，最早的响应通常是对单独的ESAT-6或对ESAT-6和其他抗原的响应。这些结果提供了ESAT-6作为抗原用于非人类灵长类动物的血清学诊断的抗原的潜在价值的实验证据。

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