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首页> 外文期刊>Comparative Medicine >Liposome-encapsulated oxymorphone hydrochloride provides prolonged relief of postsurgical visceral pain in rats
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Liposome-encapsulated oxymorphone hydrochloride provides prolonged relief of postsurgical visceral pain in rats

机译：脂质体包裹的盐酸羟吗啡酮可长时间缓解大鼠手术后内脏痛

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Adequate pain control is necessary for optimal postsurgical recovery and humane treatment of laboratory and companion animals. Opioid drugs are currently the most potent analgesic agents available in human and veterinary medicine. Long-acting formulations of opioid drugs confer several important advantages over standard pharmaceutical preparations, especially for use in animals. A long-acting formulation of oxymorphone hydrochloride was produced by encapsulation into liposomes. Liposome-encapsulated (LE) oxymorphone was tested in a rat model of visceral postoperative pain. Rats were given one subcutaneous injection of LE oxymorphone (1.2 or 1.6 mg/kg of body weight) or standard oxymorphone (0.3 mg/kg) at the time of intestinal transection or resection. A single administration of LE oxymorphone hydrochloride was as effective for relief of postoperative pain in rats (P = 0.18), as were multiple (q4 h or q8 h) injections of 0.3 mg/kg of the standard pharmaceutical preparation. The rats given LE oxymorphone prior to intestinal resection also had significantly higher body weight at three and seven days after surgery than did rats that were given standard oxymorphone. In conclusion, LE oxymorphone was effective in treating visceral pain associated with intestinal surgery in rats. On the basis of body weight gain, rats treated with LE oxymorphone had improved recovery outcome, compared with rats treated with repeated injections of standard oxymorphone.
机译：适当的疼痛控制对于实验室和陪伴动物的最佳术后恢复和人道治疗是必要的。阿片类药物目前是人类和兽医学中最有效的止痛药。与标准药物制剂相比，阿片类药物的长效制剂具有多个重要优势，尤其是用于动物的制剂。盐酸羟吗啡酮的长效制剂是通过将其包封到脂质体中制成的。在大鼠内脏术后疼痛模型中测试了脂质体包裹的羟吗啡酮。在肠横切或切除时，给大鼠皮下注射LE羟吗啡酮（1.2或1.6 mg / kg体重）或标准羟吗啡酮（0.3 mg / kg）。单次使用盐酸盐酸羟吗啡酮可有效减轻大鼠术后疼痛（P = 0.18），与多次（q4 h或q8 h）注射0.3 mg / kg的标准药物制剂一样有效。肠切除前给予LE羟吗啡酮的大鼠在术后三天和七天的体重也显着高于接受标准羟吗啡酮的大鼠。总之，LE羟吗啡酮可有效治疗大鼠肠手术相关的内脏痛。根据体重增加，与反复注射标准羟吗啡酮治疗的大鼠相比，LE羟吗啡酮治疗的大鼠具有改善的恢复结果。

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