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首页> 外文期刊>Comparative Medicine >Detection of systemic amyloidosis in the pig-tailed macaque (Macaca nemestrina).
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Detection of systemic amyloidosis in the pig-tailed macaque (Macaca nemestrina).

机译：猪尾猕猴（Macaca nemestrina）中系统性淀粉样变性的检测。

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摘要

Secondary amyloidosis is a progressive systemic disease for which there is no reliable diagnostic assay, preventive measure, or treatment. In an attempt to elucidate an antemortem diagnosis, 30 female pig-tailed macaques (Macaca nemestrina) at the Washington National Primate Research Center were surveyed for amyloidosis. Amyloid was demonstrated histologically in 47% (14 of 30) of the animals. The distribution and severity of amyloid deposition was variable. Affected animals had a mean age (+or-1 standard deviation) of 13.2+or-4.9 y, which was significantly greater than the mean age of unaffected animals (9.3+or-4.1) y. Twelve tests were evaluated for detection of amyloidosis; the diagnostic value of each was determined through comparison of histologically positive and histologically negative animals. Diagnostic tests evaluated were endoscopic examination and biopsy of the stomach and colon, abdominal ultrasonography, hepatic radiology, serum amyloid A (SAA), endothelin 1, alpha-fetal protein, aspartate aminotransferase (AST), alanine aminotransferase, gamma-glutamyltransferase (GGT), alkaline phosphatase, cholesterol, blood urea nitrogen, total bilirubin, C-reactive proteins, and erythrocyte sedimentation rate. Amyloidotic animals demonstrated a distinctive serologic profile: elevated SAA, GGT, and AST in combination with decreased total protein and albumin. Radiology demonstrated hepatomegaly in animals with hepatic amyloid deposition. In the absence of known infection or trauma, an amyloidotic serologic profile and radiologic hepatomegaly are consistent with systemic amyloidosis in M. nemestrina..
机译：继发性淀粉样变性病是一种进行性系统疾病，尚无可靠的诊断方法，预防措施或治疗方法。为了阐明死前诊断，对华盛顿国家灵长类动物研究中心的30只雌性猪尾猕猴（Macaca nemestrina）进行了淀粉样变性调查。在47％（30只中的14只）动物中，组织学上显示出淀粉样蛋白。淀粉样蛋白沉积的分布和严重程度是可变的。患病动物的平均年龄（+或-1标准偏差）为13.2+或-4.9 y，显着大于未患病动物的平均年龄（9.3+或-4.1）y。评估了十二项测试以检测淀粉样变性。通过比较组织学阳性和组织学阴性动物来确定每种动物的诊断价值。评估的诊断测试包括内窥镜检查和胃和结肠活检，腹部超声检查，肝脏放射学，血清淀粉样蛋白A（SAA），内皮素1，α-胎儿蛋白，天冬氨酸转氨酶（AST），丙氨酸转氨酶，γ-谷氨酰转氨酶（GGT） ，碱性磷酸酶，胆固醇，血液尿素氮，总胆红素，C反应蛋白和红细胞沉降率。淀粉样变性动物表现出独特的血清学特征：SAA，GGT和AST升高，总蛋白和白蛋白降低。放射学证实动物肝内有淀粉样蛋白沉积。在没有已知的感染或创伤的情况下，淀粉样变性的血清学特征和放射性肝肿大与线虫中的全身性淀粉样变性一致。

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