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首页> 外文期刊>日本神经精神药理学会志 >Dorsal Raphe Nucleus Serotonin Neurons in WKY Rats Demonstrate Subresponsivity to an Acute Application of Escitalopram: Effect of Repeated Escitalopram Treatment
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Dorsal Raphe Nucleus Serotonin Neurons in WKY Rats Demonstrate Subresponsivity to an Acute Application of Escitalopram: Effect of Repeated Escitalopram Treatment

机译：WKY大鼠背缝核5-羟色胺神经元表明对急性应用依他普仑具有亚反应性：重复使用依他普仑治疗的效果

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摘要

Given that the Wistar Kyoto (WKY) rat is a putative animal model of depression, the present study examined the effects of acute escitalopram (ESCIT) on the dorsal raphe nucleus (DRN) serotonin (5-HT) neuron and behavior in WKY rats in comparison to Wistar rats. Furthermore, the effect of the repeated ESCIT (5 mg/kg/day s.c. for 14 days) treatment in WKY rats was assessed. Depression-like behavior was evaluated by using forced swim test (FST). Extracellular 5-HT levels were determined from the DRN and the prefrontal cortex (PFC) using microdialysis with HPLC-ECD by means of dual-probe microdialysis. Tryptophan hydroxylase was detected by Western blotting. Neuronal firing activity of DRN 5-HT neurons was assessed using extracellular single-unit in vivo electrophysiology.
机译：鉴于Wistar Kyoto（WKY）大鼠是抑郁的推定动物模型，本研究研究了急性依他普仑（ESCIT）对WKY大鼠背缝核（DRN）血清素（5-HT）神经元和行为的影响。与Wistar大鼠比较。此外，评估了在WKY大鼠中重复ESCIT（5mg / kg /天，皮下注射持续14天）治疗的效果。使用强迫游泳测试（FST）评估抑郁症样行为。通过双探针微透析，使用HPLC-ECD进行微透析，从DRN和前额叶皮层（PFC）确定细胞外5-HT水平。通过蛋白质印迹检测色氨酸羟化酶。使用细胞外单细胞体内电生理学评估DRN 5-HT神经元的神经元放电活性。

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