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Procurement of Human Tissues for Research Banking in the Surgical Pathology Laboratory: Prioritization Practices at Washington University Medical Center

机译：在手术病理实验室中为研究银行提供人体组织的采购：华盛顿大学医学中心的优先实践

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摘要

Academic hospitals and medical schools with research tissue repositories often derive many of their internal human specimen acquisitions from their site’s surgical pathology service. Typically, such acquisitions come from appropriately consented tissue discards sampled from surgical resections. Because the practice of surgical pathology has patient care as its primary mission, competing needs for tissue inevitably arise, with the requirement to preserve adequate tissue for clinical diagnosis being paramount. A set of best-practice gross pathology guidelines are summarized here, focused on the decision for tissue banking at the time specimens are macroscopically evaluated. These reflect our collective experience at Washington University School of Medicine, and are written from the point of view of our site biorepository. The involvement of trained pathology personnel in such procurements is very important. These guidelines reflect both good surgical pathology practice (including the pathologic features characteristic of various anatomic sites) and the typical objectives of research biorepositories. The guidelines should be helpful to tissue bank directors, and others charged with the procurement of tissues for general research purposes. We believe that appreciation of these principles will facilitate the partnership between surgical pathologists and biorepository directors, and promote both good patient care and strategic, value-added banking procurements.
机译：具有研究组织存储库的学术医院和医学院通常从其现场的手术病理服务中获取许多内部人体标本。通常，此类采集来自从手术切除中采样得到的适当同意的组织丢弃物。由于手术病理学的主要任务是患者护理，因此不可避免地会出现组织竞争的需求，而保留足够的组织用于临床诊断至关重要。这里总结了一组最佳实践的总体病理学指南，重点是在宏观评估标本时进行组织保存的决策。这些反映了我们在华盛顿大学医学院的集体经验，并且是从我们站点生物存储库的角度编写的。受过训练的病理学人员参与此类采购非常重要。这些指南既反映了良好的手术病理学实践（包括各种解剖部位的病理特征），也反映了研究生物资源库的典型目标。该指南对组织库主任以及负责一般研究目的组织采购的其他组织应有所帮助。我们相信，对这些原则的赞赏将促进外科病理学家和生物库主管之间的合作，并促进良好的患者护理以及战略性，增值性银行采购。

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