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首页> 外文期刊>Biopreservation and biobanking >Feasibility of linking population-based cancer registries and cancer center biorepositories (Conference Paper)
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Feasibility of linking population-based cancer registries and cancer center biorepositories (Conference Paper)

机译：将基于人群的癌症注册机构与癌症中心生物存储库联系起来的可行性（会议论文）

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Purpose: Biospecimen-based research offers tremendous promise as a way to increase understanding of the molecular epidemiology of cancers. Population-based cancer registries can augment this research by providing more clinical detail and long-term follow-up information than is typically available from biospecimen annotations. In order to demonstrate the feasibility of this concept, we performed a pilot linkage between the California Cancer Registry (CCR) and the University of California, Davis Cancer Center Biorepository (UCD CCB) databases to determine if we could identify patients with records in both databases. Methods: We performed a probabilistic data linkage between 2180 UCD CCB biospecimen records collected during the years 2005-2009 and all CCR records for cancers diagnosed from 1988-2009 based on standard data linkage procedures. Results: The 1040 UCD records with a unique medical record number, tissue site, and pathology date were linked to 3.3 million CCR records. Of these, 844 (81.2%) were identified in both databases. Overall, record matches were highest (100%) for cancers of the cervix and testis/other male genital system organs. For the most common cancers, matches were highest for cancers of the lung and respiratory system (93%), breast (91.7%), and colon and rectum (89.5%), and lower for prostate (72.9%). Conclusions: This pilot linkage demonstrated that information on existing biospecimens from a cancer center biorepository can be linked successfully to cancer registry data. Linkages between existing biorepositories and cancer registries can foster productive collaborations and provide a foundation for virtual biorepository networks to support population-based biospecimen research.
机译：目的：基于生物样本的研究提供了巨大的希望，可以作为增进对癌症分子流行病学认识的一种方式。基于人群的癌症注册管理机构可以提供比通常从生物样本注释中获得的更多临床细节和长期随访信息，从而扩大这项研究的范围。为了证明此概念的可行性，我们在加利福尼亚州癌症登记处（CCR）和加利福尼亚大学戴维斯分校癌症中心生物存储库（UCD CCB）数据库之间进行了试验性链接，以确定我们是否可以在两个数据库中均找到具有记录的患者。方法：根据标准数据链接程序，我们在2005-2009年收集的2180个UCD CCB生物样本记录与1988-2009年诊断出的所有癌症CCR记录之间进行了概率数据链接。结果：具有独特病历编号，组织部位和病理日期的1040条UCD记录与330万CCR记录相关。在这两个数据库中，有844个（81.2％）被确定。总体而言，子宫颈癌和睾丸癌/其他男性生殖系统器官癌的记录匹配率最高（100％）。对于最常见的癌症，肺癌和呼吸系统癌症（93％），乳腺癌（91.7％），结肠和直肠癌（89.5％）的匹配最高，而前列腺癌（72.9％）的匹配较低。结论：这项初步的联系表明癌症中心生物库中现有生物标本的信息可以成功地与癌症登记数据联系起来。现有生物资源库与癌症登记处之间的联系可以促进富有成效的合作，并为虚拟生物资源库网络提供基础，以支持基于人群的生物样本研究。

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