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首页> 外文期刊>Comparative Medicine >Proteinuria of nonautoimmune origin in wild-type FVB/NJ mice
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Proteinuria of nonautoimmune origin in wild-type FVB/NJ mice

机译：野生型FVB / NJ小鼠的非自身免疫性蛋白尿

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摘要

FVB/NJ mice frequently are used as transgenic hosts, but the suitability of this genetic background for transgenic and congenic models of systemic autoimmunity have not been reported. In this study, FVB/NJ mice were evaluated for the presence of serum autoantibodies and autoimmune kidney pathology. Previously unreported albuminuria was observed in aged female FVB/NJ mice; however, serum autoantibody testing, light microscopic evaluation of differentially stained renal sections, and evaluation of renal sections for immunoglobulin deposits revealed that the albuminuria was not of autoimmune etiology. Anecdotally, multiple characteristics of the FVB/NJ strain, including albuminuria, cholesterolemia, mild podocyte foot process effacement in aged female FVB/NJ kidneys and predisposition to enhanced Th2 immune responses, is reminiscent of human minimal change nephrotic syndrome (MCNS). We propose that mapping of genetic polymorphisms that are responsible for these traits in FVB/NJ mice may lead to increased understanding of mild nephrotic syndromes including MCNS and other proteinurias.
机译：FVB / NJ小鼠经常被用作转基因宿主，但尚未报道该遗传背景对全身性自身免疫的转基因和同基因模型的适用性。在这项研究中，评估了FVB / NJ小鼠的血清自身抗体和自身免疫性肾脏病理。在老年雌性FVB / NJ小鼠中观察到以前未报告的蛋白尿;然而，血清自身抗体测试，差异染色的肾脏切片的光学显微镜评估以及免疫球蛋白沉积物的肾脏切片评估显示白蛋白尿不是自身免疫病因。有趣的是，FVB / NJ菌株的多种特征，包括白蛋白尿，胆固醇血症，老年女性FVB / NJ肾脏中的轻度足细胞足突脱皮以及易患Th2免疫应答，这使人联想到人类微小变化性肾病综合征（MCNS）。我们建议对FVB / NJ小鼠中这些特征负责的遗传多态性作图可能导致对轻度肾病综合征（包括MCNS和其他蛋白尿）的了解增加。

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