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The Human Face of Biobank Networks for Translational Research

机译：用于转化研究的生物库网络的人脸

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The biobanking literature frequently addresses donor and societal issues surrounding biobanking, but the biobanker’s perspective is rarely highlighted. While not comprehensive, this article offers an overview of the human aspects of biobanking from the viewpoint of biobank personnel—from biobank formation, through the process, and in addressing post-biobanking issues. As every biobank and biobank network may differ, such factors may vary. Before biobanking can commence, the purpose of the biobank network must be defined, and buy-in achieved from many stakeholders. An attitude of trust and sharing is essential, as is good communication. Developing a biobank is time consuming and laborious. Forming a network requires significantly more time due to the need for cross-institutional harmonization of policies, procedures, information technology considerations, and ethics. Circumstances may dictate whether development occurs top-down and/or bottomup,as well as whether network management may be independent or by personnel from participating biobanks. Funding tends to be a prominent issue for biobanks and networks alike. In particular, networks function optimally with some level of government support, particularly for personnel. Quality biospecimen collection involves meticulously documented coordination with a network of medical and nursing staff. Examining and sampling operative specimens requires timely collaboration between the surgical and pathology teams. ‘‘Catch rates’’ for samples may be difficult to predict and may occur at a frequency less than anticipated due to factors related to the institution, staff, or specimen. These factors may affect specimen quality, and have a downstream effect on competition for specimens for research. Thus, release of samples requires a fair, carefully constructed sample access policy, usually incorporating an incentive for researchers, and an encouragement to form collaborations. Finally, the public and patient groups should aim to understand the benefits of a biobank network, so that patient care is improved through coordinated biobanking activity.
机译：生物银行文献经常涉及生物银行的捐助者和社会问题，但很少强调生物银行的观点。本文虽然不全面，但从生物库人员的角度概述了生物库的人类方面，从生物库的形成，整个过程到解决生物后库问题。由于每个生物库和生物库网络都可能不同，因此这些因素可能会有所不同。在开始生物银行之前，必须确定生物银行网络的目的，并从许多利益相关者处实现买进。信任和分享的态度至关重要，良好的沟通也是如此。发展生物库既费时又费力。由于需要跨机构协调政策，程序，信息技术考虑因素和道德规范，因此组建网络需要大量时间。环境可能会决定开发过程是自上而下和/或自下而上发生，以及网络管理是独立的还是参与生物银行的人员管理。对于生物银行和网络而言，资金筹集往往是一个突出的问题。特别是，网络在某些级别的政府支持下（特别是对人员而言）发挥最佳作用。高质量的生物样本采集涉及与医护人员网络精心记录的协调。检查和取样手术标本需要手术和病理团队之间的及时合作。样本的“捕获率”可能难以预测，并且由于与机构，员工或样本有关的因素，其发生频率可能​​低于预期。这些因素可能会影响标本质量，并对研究标本的竞争产生下游影响。因此，发布样本需要公平，精心构建的样本访问政策，通常包括对研究人员的激励和鼓励开展合作。最后，公众和患者群体应着眼于了解生物库网络的益处，以便通过协调的生物库活动来改善患者护理。

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