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Following nature's lead: Generating compounds for stabilizing biomolecules

机译：遵循自然界的先驱：生成稳定生物分子的化合物

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摘要

We describe here a unique approach to identifying small molecules that are useful in stabilizing biomolecules in the dry and liquid states. Using biostability screens aided by in silico docking experiments and synthetic chemistry, libraries of biostability molecules are analyzed for their ability to protect important biological materials. In the case of DNA stabilization in the dry state, interactions of suitable candidate biostability compounds with DNA are studied in initial screens to identify their ability to form glasses at elevated temperatures. The most promising compounds are then tested for their capacity to preserve DNA during long-term storage. The results have led to a commercial product for storage of DNA that is being adopted for many commercial and experimental applications. Further studies have shown that small molecules for preservation of RNA, proteins, and tissue samples can be developed by following the same progression of screens.
机译：我们在这里描述一种识别小分子的独特方法，该小分子可用于稳定处于干燥和液态状态的生物分子。在计算机对接实验和合成化学的帮助下，利用生物稳定性筛选，分析了生物稳定性分子库保护重要生物材料的能力。如果DNA在干燥状态下稳定，则在初始筛选中研究合适的候选生物稳定性化合物与DNA的相互作用，以确定它们在高温下形成玻璃的能力。然后测试最有前途的化合物在长期保存过程中保存DNA的能力。结果导致了一种用于存储DNA的商业产品，被许多商业和实验应用所采用。进一步的研究表明，通过遵循相同的筛选过程，可以开发出用于保存RNA，蛋白质和组织样品的小分子。

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