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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Effects of bilateral nephrectomy and angiotensin II replacement on body fluids in foetal sheep.
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Effects of bilateral nephrectomy and angiotensin II replacement on body fluids in foetal sheep.

机译：双侧肾切除术和血管紧张素II替代对胎羊体液的影响。

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1. To determine the importance of the kidneys in maintaining the normal volume and composition of foetal body fluids, measurements were made in 11 chronically catheterized foetuses (123-136 days) that had been bilaterally nephrectomized at least 5 days previously and compared with 10 intact foetuses (121-133 days). 2. The nephrectomized foetuses had reduced extracellular (ECV), blood, plasma and interstitial volumes per kg foetal weight (P < 0.005), reduced plasma chloride levels (P < 0.001) and were acidaemic, hypoxaemic and hypercapnaemic (P < 0.05) compared with intact foetuses. They also had reduced lung liquid production (P < 0.05) and reduced lung liquid sodium and osmolality levels (P < 0.05). Their arterial pressure was more variable between foetuses (P < 0.005) and was directly related to ECV/kg (P = 0.013). 3. To determine which of these changes were due to absence of the foetal renin-angiotensin system, seven chronically catheterized nephrectomized foetal sheep (124-132 days) were infused with replacement doses of angiotensin (Ang)II (1.5 micrograms/kg per h) for 3 days. Six nephrectomized foetuses were infused with 0.15 mol/L saline. 4. The AngII infusion was non-pressor. It prevented the fall in ECV that occurred in the control group (P < 0.05) and foetal plasma chloride concentration rose (P < 0.05). Blood gas status and lung liquid production rate did not change, but lung liquid sodium concentration fell (P < 0.05) and potassium concentration rose (P < 0.05). 5. Bolus injections of AngII (0.3-5 micrograms) were given to assess vascular sensitivity to AngII. This was not altered by either nephrectomy or AngII replacement. 6. It is concluded that the foetal kidneys are important for the maintenance of the normal volume and composition of foetal body fluids. Angiotensin II, perhaps because it promotes fluid transfer across the placenta, helps maintain foetal ECV and plasma chloride levels.
机译：1.为了确定肾脏在维持胎儿体液正常体积和组成中的重要性，对至少在5天前双侧肾切除了11例经慢性肾切除术的慢性导管胎儿进行了测量（123-136天）。胎儿（121-133天）。 2.肾切除的胎儿每千克胎儿的细胞外（ECV），血液，血浆和间质体积减少（P <0.005），血浆氯化物水平降低（P <0.001），并且具有酸血症，低氧血症和高碳酸血症（P <0.05）与完整的胎儿。他们还降低了肺液产生量（P <0.05），并降低了肺液钠和渗透压浓度（P <0.05）。他们的动脉压在胎儿之间变化更大（P <0.005），并且与ECV / kg直接相关（P = 0.013）。 3.为了确定其中哪些变化是由于缺乏胎儿肾素-血管紧张素系统所致，对七只经慢性导管切除的经肾切除的胎羊（124-132天）注入了替代剂量的血管紧张素（Ang）II（1.5微克/千克/小时）的3天。向六个肾切除的胎儿注入0.15 mol / L盐水。 4. AngII输注为非加压药。它可以防止对照组发生ECV下降（P <0.05）和胎儿血浆氯化物浓度上升（P <0.05）。血气状态和肺液产生率没有变化，但肺液钠浓度下降（P <0.05），钾浓度上升（P <0.05）。 5.给予Bolus注射AngII（0.3-5微克）以评估血管对AngII的敏感性。肾切除术或AngII替代都不能改变这一点。 6.结论是，胎儿肾脏对于维持胎儿体液的正常体积和成分很重要。血管紧张素II也许是因为它促进了通过胎盘的液体转移，有助于维持胎儿的ECV和血浆氯化物水平。

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