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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Effects of post-treatment with low-dose propofol on inflammatory responses to lipopolysaccharide-induced shock in conscious rats.
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Effects of post-treatment with low-dose propofol on inflammatory responses to lipopolysaccharide-induced shock in conscious rats.

机译：小剂量异丙酚后处理对清醒大鼠对脂多糖诱导的休克的炎症反应的影响。

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SUMMARY 1. In the present study, we used a low dose of propofol (5 mg/kg per h) to investigate its effects on the pro-inflammatory cytokines (tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-10) and changes in nitric oxide (NO) following lipopolysaccharide (LPS) for a period of 12 h in conscious rats. 2. Experiments were designed to induce endotoxin shock by intravenous injection of Klebsiella pneumoniae LPS (10 mg/kg) in conscious rats. Arterial pressure (AP) and heart rate (HR) were monitored continuously for 12 h after LPS administration. Tumour necrosis factor-alpha, IL-1beta, IL-10 and plasma nitratesitrites were determined before and 0.5, 1, 3, 6, 9 and 12 h after LPS administration. A low dose of intravenous propofol (5 mg/kg per h) was administered to investigate the effects on cytokine responses and changes in NO in endotoxin shock. 3. Lipopolysaccharide significantly increased TNF-alpha, IL-1beta, IL-10, nitritesitrates and HR, whereas mean AP was decreased. Post-treatment with propofol suppressed the release of TNF-alpha, IL-1beta, IL-10 and NO production after endotoxin shock. 4. Lipopolysaccharide also caused a decrease in the white blood cell count and haematocrit. 5. Post-treatment with propofol slightly, but not significantly, affected the LPS-induced systemic hypotension, tachycardia, leukocytopenia and anaemia. 6. These findings suggest that low-dose propofol may be beneficial to the inflammatory change in sepsis.
机译：总结1.在本研究中，我们使用了低剂量的异丙酚（每小时5 mg / kg）来研究其对促炎细胞因子（肿瘤坏死因子（TNF）-α，白介素（IL）-1beta和IL-10）和脂多糖（LPS）引起的清醒大鼠中一氧化氮（NO）的变化持续12 h。 2.设计实验，通过在意识清醒的大鼠中静脉注射肺炎克雷伯菌LPS（10 mg / kg）诱导内毒素休克。 LPS给药后12小时连续监测动脉压（AP）和心率（HR）。在LPS给药之前和给药0.5、1、3、6、9和12小时后测定肿瘤坏死因子-α，IL-1β，IL-10和血浆硝酸盐/亚硝酸盐。低剂量的静脉注射异丙酚（每小时5 mg / kg）用于研究内毒素休克对细胞因子反应和NO变化的影响。 3.脂多糖显着增加TNF-α，IL-1β，IL-10，亚硝酸盐/硝酸盐和心率，而平均AP降低。丙泊酚的后处理抑制了内毒素休克后TNF-α，IL-1β，IL-10和NO的释放。 4.脂多糖还引起白细胞计数和血细胞比容降低。 5.丙泊酚的后处理对LPS引起的系统性低血压，心动过速，白细胞减少和贫血有轻微但不明显的影响。 6.这些发现表明，小剂量的异丙酚可能对败血症的炎症改变有益。

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