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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Effects of 1,8-cineole on electrophysiological parameters of neurons of the rat superior cervical ganglion.
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Effects of 1,8-cineole on electrophysiological parameters of neurons of the rat superior cervical ganglion.

机译：1,8-桉树脑对大鼠颈上神经节神经元电生理参数的影响。

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1. 1,8-Cineole is a non-toxic small terpenoid oxide believed to have medicinal properties in folk medicine. It has been shown to have various pharmacological effects, including blockade of the compound action potential (AP). In the present study, using intracellular recording techniques, we investigated the effects of 1,8-cineole on the electrophysiological parameters of neurons of the superior cervical ganglion (SCG) in rats. 2. 1,8-Cineole (0.1-6 mmol/L) showed reversible and concentration-dependent effects on various electrophysiological parameters. At 3 and 6 mmol/L, but not at 0.1 and 1 mmol/L, 1,8-cineole significantly diminished the input resistance (R(i)) and altered the resting potential (E(m)) to more positive values. At 6 mmol/L, 1,8-cineole completely blocked all APs within 2.7 +/- 0.6 min (n = 12). In neurons exposed to 3 and 1 mmol/L 1,8-cineole, the effects regarding excitability varied from complete AP blockade to minor inhibition of AP parameters. The depolarization of E(m) and the decrease in R(i) induced by 6 mmol/L 1,8-cineole were unaltered by 200 micromol/L niflumic acid, a well known blocker of Ca(2+)-activated Cl(-) currents. 3. Significant correlations (Pearson correlation test) were found between changes in E(m) and decreases in AP amplitude (r = -0.893; P < 0.00282) and maximum ascendant inclination (r = -0.799; P < 0.0173), but not for maximum descendant inclination (r = 0.598; P < 0.117). Application of current to restore the transmembrane potential equal to control E(m) values in the presence of 6 mmol/L 1,8-cineole resulted in the partial recovery of AP. 4. The present study shows that 1,8-cineole effectively blocks the excitability of SCG neurons, probably through various mechanisms, one of which acts indirectly via depolarization of the neuronal cytoplasmatic membrane.
机译：1. 1,8-Cineole是一种无毒的小萜类氧化物，被认为在民间医学中具有药用特性。已显示它具有多种药理作用，包括阻断复合作用电位（AP）。在本研究中，我们使用细胞内记录技术，研究了1,8-桉树脑对大鼠上颈神经节（SCG）神经元电生理参数的影响。 2. 1,8-Cineole（0.1-6 mmol / L）对各种电生理参数表现出可逆和浓度依赖性的作用。在3和6 mmol / L时，而不是在0.1和1 mmol / L时，1,8-桉树脑显着降低了输入电阻（R（i）），并将静息电位（E（m））更改为更正的值。在6 mmol / L下，1,8-桉树脑在2.7 +/- 0.6分钟内（n = 12）完全阻断了所有AP。在暴露于3和1 mmol / L 1,8-桉树脑的神经元中，关于兴奋性的影响从完全的AP阻滞到轻微的AP参数抑制不等。 E（m）的去极化和6 mmol / L 1,8-桉树脑诱导的R（i）的降低不受200 micromol / L尼氟酸（一种众所周知的Ca（2+）活化Cl（）的阻滞剂）的影响-）电流。 3.发现E（m）的变化与AP振幅的下降（r = -0.893; P <0.00282）和最大上升倾角（r = -0.799; P <0.0173）之间存在显着的相关性（Pearson相关检验），但没有最大后代倾斜度（r = 0.598; P <0.117）。在6 mmol / L 1,8-桉树脑存在下，施加电流以恢复等于对照E（m）值的跨膜电位导致AP的部分恢复。 4.本研究表明，1，8-桉树脑可能通过多种机制有效地阻断了SCG神经元的兴奋性，其中一种机制是通过神经细胞质膜去极化而间接起作用。

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