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Novel method for rapid reversal of drug toxicity: A case report

机译：快速逆转药物毒性的新方法：一例报告

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Drug toxicity is traditionally treated by reducing the amount of the drug absorbed, enhancing elimination, and providing supportive care. Once the drug has been absorbed, there are few methods that help decrease morbidity and mortality caused by a toxic drug level. Albumin infusion is a new approach that changes that, as it can rapidly reverse a toxic drug level back to a therapeutic level. It is believed with most drugs that the toxic effects are related to the total amount of the free drug. In this method, albumin binds to the free drug and acts as a reservoir or depot from which the drug is slowly released to the free form, thereby limiting the effects of drug toxicity. In this case report, an elderly female patient who experienced phenytoin toxicity was treated with albumin infusion, after which her phenytoin level returned to a therapeutic level with corresponding improvements in her symptoms. Based on our calculations, it was predicted that a small amount of albumin would reverse the patient's toxic symptoms. With this approach, the patient's toxic symptoms improved when free phenytoin levels dropped from 15 to 8 μmol/L. Albumin infusion is a promising new therapy that can rapidly reverse a toxic drug level back to a therapeutic level by binding the free drug to albumin.
机译：传统上，药物毒性的治疗是通过减少吸收的药物量，增强消除效果并提供支持性护理来进行的。药物被吸收后，几乎没有什么方法可以帮助降低由有毒药物引起的发病率和死亡率。输注白蛋白是一种新方法，它可以改变这种情况，因为它可以迅速将有毒药物的水平恢复到治疗水平。相信对于大多数药物来说，毒性作用与游离药物的总量有关。在这种方法中，白蛋白与游离药物结合并充当储库或储库，药物从储库或储库缓慢释放成游离形式，从而限制了药物毒性的作用。在该病例报告中，对一名经历苯妥英钠中毒的老年女性患者进行了白蛋白输注治疗，此后她的苯妥英钠水平恢复到治疗水平，症状得到相应改善。根据我们的计算，预计少量白蛋白会逆转患者的中毒症状。通过这种方法，当游离苯妥英水平从15降至8μmol/ L时，患者的毒性症状得到改善。白蛋白输注是一种有前途的新疗法，通过将游离药物与白蛋白结合，可以迅速将有毒药物水平恢复到治疗水平。

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