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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Low-dose metronomic chemotherapy with cisplatin enhanced immunity in a murine model of ectopic cervical cancer
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Low-dose metronomic chemotherapy with cisplatin enhanced immunity in a murine model of ectopic cervical cancer

机译：异位子宫颈癌小鼠模型中的小剂量节律化疗联合顺铂增强免疫力

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Previous researchers have claimed that metronomic low-dose/dense chemotherapy can enhance the therapeutic effectiveness of cisplatin treatment in the control of cancer. Therefore, the aim of this study was to explore the effectiveness of metronomic drug delivery with regards to its effects on adaptive immunity in a murine model of ectopic cervical cancer. The effectiveness of long-term low-dose/dense cisplatin treatment in HPV E7-expressing TC-1 cells was evaluated via morphological observations. Tumour mass and survival curves were used to determine the antitumour effect against E7-expressing tumours. After experimental mice had been treated with low-dose/dense cisplatin therapy, flow cytometry was used to measure the expression of MHC class I surface antigens on cultured TC-1 cells. Splenocytes expressing both interferon (IFN)-γ and CD8 responsible for E7 antigens and the Treg population were also quantified using flow cytometry. The results indicate that in vivo treatment with metronomic cisplatin suppresses the growth of cultured TC-1 cells. An increase was also observed in the number of splenocytes expressing both IFN-γ and CD8 responsible for E7 antigens and the Treg population. These results support previous reports that metronomic low-dose/dense cisplatin chemotherapy is an effective treatment against ectopic cervical cancer with E7-expression.
机译：先前的研究人员声称，节律性小剂量/密集化疗可增强顺铂治疗在控制癌症中的治疗效果。因此，本研究的目的是探讨在对异位子宫颈癌小鼠模型中节律性药物递送对适应性免疫的影响方面的有效性。通过形态学观察评估了长期低剂量/致密顺铂治疗表达HPV E7的TC-1细胞的有效性。肿瘤质量和存活曲线用于确定对表达E7的肿瘤的抗肿瘤作用。用低剂量/密集顺铂疗法治疗实验小鼠后，使用流式细胞仪测量培养的TC-1细胞上MHC I类表面抗原的表达。还使用流式细胞术对表达负责E7抗原和Treg群体的干扰素（IFN）-γ和CD8的脾细胞进行了定量。结果表明，用节律性顺铂进行体内处理可抑制培养的TC-1细胞的生长。还观察到表达负责E7抗原和Treg种群的同时表达IFN-γ和CD8的脾细胞的数量增加。这些结果支持以前的报道，即节律性小剂量/密集顺铂化疗是一种有效的抗E7表达异位子宫颈癌的治疗方法。

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