...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental pharmacology & physiology >Mitochondrial decay in ageing: 'Qi-invigorating' schisandrin B as a hormetic agent for mitigating age-related diseases
【24h】

Mitochondrial decay in ageing: 'Qi-invigorating' schisandrin B as a hormetic agent for mitigating age-related diseases

机译：线粒体衰老的衰老：“益气活血”的五味子素B作为减少衰老相关疾病的止痛药

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

1. The mitochondrial free radical theory of ageing (MFRTA) proposes a primary role for mitochondrial reactive oxygen species (ROS) in the ageing process. The reductive hot spot hypothesis of mammalian ageing serves as a supplement to the MFRTA by explaining how the relatively few cells that have lost oxidative phosphorylation capacity due to mitochondrial DNA mutations can be toxic to the rest of the body and result in the development of age-related diseases. 2. Schisandrin B (SchB), which can induce both a glutathione anti-oxidant and a heat shock response via redox-sensitive signalling pathways, is a hormetic agent potentially useful for increasing the resistance of tissues to oxidative damage. The enhanced cellular/mitochondrial anti-oxidant status and heat shock response afforded by SchB can preserve the structural and functional integrity of mitochondria, suggesting a potential role for SchB in ameliorating age-related diseases. 3. Future studies will focus on investigating whether SchB can produce the hormetic response in humans.
机译：1.线粒体自由基衰老理论（MFRTA）提出了线粒体活性氧（ROS）在衰老过程中的主要作用。哺乳动物衰老的还原性热点假设通过解释相对较少的由于线粒体DNA突变而丧失氧化磷酸化能力的细胞如何对身体其余部分产生毒性并导致年龄增长而补充了MFRTA。相关疾病。 2.五味子素B（SchB），可以通过氧化还原敏感的信号传导途径诱导谷胱甘肽抗氧化剂和热休克反应，是一种可能用于增加组织对氧化损伤的抵抗力的镇静剂。 SchB提供的增强的细胞/线粒体抗氧化剂状态和热休克反应可以保持线粒体的结构和功能完整性，表明SchB在改善与年龄有关的疾病中的潜在作用。 3.未来的研​​究将集中于研究SchB是否能在人体内产生刺激反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号