...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental pharmacology & physiology >Lack of association between genetic polymorphisms of CYP3A4, CYP2C9 and CYP2C19 and antituberculosis drug-induced liver injury in a community-based Chinese population
【24h】

Lack of association between genetic polymorphisms of CYP3A4, CYP2C9 and CYP2C19 and antituberculosis drug-induced liver injury in a community-based Chinese population

机译：CYP3A4，CYP2C9和CYP2C19的遗传多态性与基于社区的中国人群抗结核药物性肝损伤之间缺乏关联

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The precise pathogenic mechanism of antituberculosis (anti-TB) drug-induced liver injury (ATLI) is poorly understood. It may be associated with drug-metabolizing enzymes, such as cytochrome P450 (CYP) 3A4, CYP2C9 and CYP2C19. The aim of the present study was to explore the role of tagging single nucleotide polymorphisms (tSNPs) of CYP3A4, CYP2C9 and CYP2C19 in the risk of ATLI in a population-based anti-TB treatment cohort. A nested case-control study was designed. Each ATLI case was matched 1: 4 with controls on the basis of age, gender, treatment history, disease severity and drug dosage. The tSNPs were selected using Haploview 4.2 based on the HapMap database of Han Chinese in Beijing and genotyped by TaqMan allelic discrimination technology. Eighty-nine patients with ATLI and 356 controls were included in the study. One tSNP in CYP3A4 (rs12333983), two in CYP2C9 (rs4918758, rs9332098) and two in CYP2C19 (rs11568732, rs4986894) were selected and genotyped. The minor allele frequencies of rs12333983, rs4918758, rs9332098, rs11568732 and rs4986894 were 36.0%, 41.4%, 1.1%, 5.7% and 35.7%, respectively, in the patients, compared with 31.7%, 42.9%, 3.4%, 8.9% and 35.1%, respectively, in the controls. No significant differences were observed in genotypes or allele frequencies of the five tSNPs between the two groups and none of the CYP2C9 or CYP2C19 haplotypes was significantly associated with the development of ATLI. Based on the Chinese anti-TB treatment cohort, we did not find a significant association between the risk of ATLI and genetic polymorphisms of CYP3A4, CYP2C9 and CYP2C19. None of the haplotypes exhibited a significant association with the development of ATLI in a Chinese tuberculosis population.
机译：人们对抗结核病（anti-TB）药物性肝损伤（ATLI）的确切致病机制知之甚少。它可能与药物代谢酶相关，例如细胞色素P450（CYP）3A4，CYP2C9和CYP2C19。本研究的目的是探讨基于人群的抗结核治疗人群中CYP3A4，CYP2C9和CYP2C19的单核苷酸多态性（tSNPs）标记在ATLI风险中的作用。设计了一个嵌套的病例对照研究。根据年龄，性别，治疗史，疾病严重程度和药物剂量，将每个ATLI病例与对照组进行1：4匹配。使用基于北京汉族HapMap数据库的Haploview 4.2选择tSNP，并通过TaqMan等位基因鉴别技术进行基因分型。该研究包括89名ATLI患者和356名对照。选择了CYP3A4中的一个tSNP（rs12333983），CYP2C9中的两个tSNP（rs4918758，rs9332098）和CYP2C19中的两个tSNP（rs11568732，rs4986894）并进行了基因分型。患者的rs12333983，rs4918758，rs9332098，rs11568732和rs4986894的次要等位基因频率分别为36.0％，41.4％，1.1％，5.7％和35.7％，而31.7％，42.9％，3.4％，8.9％和分别占对照组的35.1％。两组之间五个tSNP的基因型或等位基因频率均未观察到显着差异，CYP2C9或CYP2C19单倍型均与ATLI的发生无显着相关性。根据中国抗结核治疗人群，我们未发现ATLI风险与CYP3A4，CYP2C9和CYP2C19基因多态性之间存在显着关联。在中国结核病人群中，没有任何一种单体型与ATLI的发育有显着相关性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号