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首页> 外文期刊>Biomacromolecules >Interpenetrating Collagen-Fibrin Composite Matrices with Varying Protein Contents and Ratios
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Interpenetrating Collagen-Fibrin Composite Matrices with Varying Protein Contents and Ratios

机译：互穿的胶原蛋白-纤维蛋白复合基质具有不同的蛋白质含量和比率

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摘要

Pure and composite hydrogel matrices of collagen type I and fibrin were produced by simultaneous polymerization of each biopolymer in the presence of vascular smooth muscle cells.The ratio of collagen to fibrin in composite matrices was varied from 1:1 to 1:4,with corresponding absolute protein concentrations of 1.0-5.0 mg/mL.Constructs cultured for 7 days were subjected to uniaxial tensile testing,analysis of cell content,as well as scanning electron and confocal microscopic imaging.Gel compaction over time in culture decreased with increasing protein content but was augmented by the presence of fibrin.Material properties(modulus,ultimate tensile stress,and toughness)were highly correlated with gel compaction,protein density,and cell concentration.Maximum force at failure was dependent on absolute protein concentration.This study examined the interrelationships between protein type,ratio,and density in composite biopolymer matrices and contributes to the understanding of structure-function relationships in such materials.
机译：通过在血管平滑肌细胞存在下同时聚合每种生物聚合物来生产I型胶原蛋白和纤维蛋白的纯净和复合水凝胶基质，复合基质中胶原蛋白与纤维蛋白的比例在1：1至1：4之间变化，相应地绝对蛋白质浓度为1.0-5.0 mg / mL。对培养7天的构建体进行单轴拉伸测试，细胞含量分析以及扫描电子和共聚焦显微镜成像。随着蛋白质含量的增加，随着时间的推移，培养中的凝胶压实度降低，但纤维蛋白的存在增强了材料的性能（模量，极限拉伸应力和韧性）与凝胶紧实度，蛋白质密度和细胞浓度高度相关。最大破坏力取决于绝对蛋白质浓度。本研究考察了相互关系生物聚合物基质中蛋白质类型，比率和密度之间的关系，有助于理解结构乐趣这些材料中的关系。

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