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首页> 外文期刊>Biomacromolecules >Nature of Interactions between PEO-PPO-PEO Triblock Copolymers and Lipid Membranes: (I) Effect of Polymer Hydrophobicity on Its Ability to Protect Liposomes from Peroxidation
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Nature of Interactions between PEO-PPO-PEO Triblock Copolymers and Lipid Membranes: (I) Effect of Polymer Hydrophobicity on Its Ability to Protect Liposomes from Peroxidation

机译：PEO-PPO-PEO三嵌段共聚物与脂质膜之间相互作用的性质：（I）聚合物疏水性对其保护脂质体免受过氧化能力的影响

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摘要

PEO-PPO-PEO triblock copolymers have opposing effects on lipid membrane integrity: they can behave either as membrane sealants or as membrane permeabilizers. To gain insights into their biomembrane activities, the fundamental interactions between a series of PEO-based polymers and phospholipid vesicles were investigated. Specifically, the effect of copolymer hydrophobicity on its ability to prevent liposomes from peroxidation was evaluated, and partitioning free energy and coefficient involved in the interactions were derived. Our results show that the high degree of hydrophilicity is a key feature of the copolymers that can effectively protect liposomes from peroxidation and the protective effect of the copolymers stems from their adsorption at the membrane surface without penetrating into the bilayer core. The origin of this protective effect induced by polymer absorption is attributed to the retardation of membrane hydration dynamics, which is further illustrated in the accompanying study on dynamic nuclear polarization; (DNP)-derived hydration dynamics (Cheng, C.-Y.; Wang, J-Y.; Kausik, R.; Lee, K. Y. C., Han S. Biomacromolecules., 2012, DOI; 10.102l/bm300848c).
机译：PEO-PPO-PEO三嵌段共聚物对脂质膜的完整性具有相反的影响：它们既可以充当膜密封剂，也可以充当膜渗透剂。为了深入了解其生物膜活性，研究了一系列基于PEO的聚合物与磷脂囊泡之间的基本相互作用。具体而言，评估了共聚物疏水性对其防止脂质体过氧化的能力的影响，并推导了相互作用中涉及的分配自由能和系数。我们的结果表明，高度亲水性是共聚物的关键特征，可以有效保护脂质体免受过氧化作用，并且共聚物的保护作用源于其在膜表面的吸附而不渗透到双层核心中。聚合物吸收引起的这种保护作用的起因归因于膜水化动力学的延迟，这在伴随的动态核极化研究中得到了进一步证明。 （DNP）-衍生的水合动力学（Cheng，C.-Y .; Wang，J-Y .; Kausik，R .; Lee，K.Y.C.，Han S.Biomacromolecules。，2012，DOI; 10.102l / bm300848c）。

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