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首页> 外文期刊>Clinical and laboratory haematology >Helicobacter pylori infection is not a correlate of plasma fibrinogen in the Australian population.
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Helicobacter pylori infection is not a correlate of plasma fibrinogen in the Australian population.

机译:幽门螺杆菌感染与澳大利亚人群血浆纤维蛋白原无关。

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摘要

Plasma fibrinogen concentration is an important independent risk factor for cardiovascular disease. Studies into whether Helicobacter pylori infection and fibrinogen are associated have yielded inconsistent results. Despite the geographical variation in fibrinogen and prevalence of H. pylori infection, all studies to date have been undertaken in the United Kingdom or Italy. The association between H. pylori infection and fibrinogen was investigated in 324 adults, 65% of a random sample, in an Australian regional city. The mean plasma fibrinogen concentration in 98 infected participants (2.52 g/l) was similar to that in 226 non-infected subjects (2.58 g/l, P = 0.51); 95% confidence interval on the difference was -0.23-0.11 g/l. After including all potential confounding factors in a backward multiple linear regression analysis, H. pylori was still not associated with fibrinogen (P = 0.084). Any association between H. pylori and cardiovascular disease in Australia is not mediated through fibrinogen.
机译:血浆纤维蛋白原浓度是心血管疾病的重要独立危险因素。关于幽门螺杆菌感染和纤维蛋白原是否相关的研究产生了不一致的结果。尽管纤维蛋白原的地理差异和幽门螺杆菌感染的流行,迄今为止,所有研究均在英国或意大利进行。在澳大利亚一个地区性城市中,对324名成年人(占随机样本的65%)进行了幽门螺杆菌感染与纤维蛋白原之间的相关性研究。 98名受感染受试者的平均血浆纤维蛋白原浓度(2.52 g / l)与226名未受感染受试者的平均血浆纤维蛋白原浓度(2.58 g / l,P = 0.51)相似。差异的95%置信区间为-0.23-0.11 g / l。在向后多元线性回归分析中包括所有潜在的混杂因素后,幽门螺杆菌仍未与纤维蛋白原相关(P = 0.084)。在澳大利亚,幽门螺杆菌与心血管疾病之间的任何关联都不是通过纤维蛋白原介导的。

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