首页> 外文期刊>Clinical and laboratory haematology >Double esterase staining of the bone marrow contributes to lineage identification in a case of minimally differentiated acute myeloid leukaemia (AML M0).
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Double esterase staining of the bone marrow contributes to lineage identification in a case of minimally differentiated acute myeloid leukaemia (AML M0).

机译:在最低分化的急性髓细胞性白血病(AML M0)的情况下,骨髓的双酯酶染色有助于谱系鉴定。

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摘要

Minimally differentiated acute myeloid leukaemia (AML-M0) may pose difficulty in diagnosis since morphological criteria alone are not reliable. Other studies such as electron microscopy, immunocytochemistry and surface marker analysis are needed. The role of cytochemistry has been limited to the negative staining of blasts for Sudan Black B and myeloperoxidase. An abnormal morphology and cytochemistry of bone marrow maturing cells may indicate the myeloid nature of acute leukaemia. In this case of AML-M0, increased numbers of maturing and mature bone marrow granulocytic cells staining simultaneously for both specific and non-specific esterase (double esterase) are described. In acute leukaemia, this abnormal cytochemical finding seems to be specific for myeloid leukaemia and may be used as supplementary evidence of myeloid differentiation of morphologically undifferentiated blasts in cases of AML-M0.
机译:由于单独的形态学标准不可靠,因此最低分化的急性髓细胞性白血病(AML-M0)可能会给诊断带来困难。还需要其他研究,例如电子显微镜,免疫细胞化学和表面标记分析。细胞化学的作用仅限于苏丹黑B和髓过氧化物酶母细胞的阴性染色。骨髓成熟细胞的形态学和细胞化学异常可能表明急性白血病的髓样性质。在AML-M0的情况下,描述了同时针对特异性和非特异性酯酶(双酯酶)染色的成熟和成熟的骨髓颗粒细胞数目增加。在急性白血病中,这种异常的细胞化学发现似乎是髓性白血病所特有的,在AML-M0病例中,可以用作形态学上未分化胚细胞的髓样分化的补充证据。

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